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ProteomicsPivotal role for S-nitrosylation of DNA methyltransferase in epigenetic regulation
DNMTs catalyze the methylation of cytosine with SAM. DNA methylation affects key cellular processes by regulating gene expression, thus serving a variety of physiological and pathophysiological roles. However, the chemical mechanisms of DNA methylation by which its enzymatic activity is regulated ha...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD039437 | Pride
No Cancer S-nitrosylation Dna methylation Epigenetics 
TranscriptomicsDifferent levels of canonical Wnt signaling exert distinct roles in the colonic epithelium
There is a gradient of M-NM-2-catenin expression along the colonic crypt axis with the highest levels at the crypt bottom. However, it remains unclear whether different levels of canonical Wnt signaling exert distinct roles in the colonic epithelium. In the present study, we first showed that the ca...
ORGANISM(S): Mus musculus 
2013-01-22 | E-GEOD-41688 | biostudies-arrayexpress
UnknownA machine learning model for predicting the lymph node metastasis of early gastric cancer not meeting the endoscopic curability criteria.
Not available
S-EPMC11335823 | biostudies-literature
TranscriptomicsOligoarray analysis of semi-global gene expression in ripening Japanese pear fruit
A custom oligoarray of Japanese pear (Pyrus pyrifolia) based on 9,812 independent ESTs from different tissues (fruits at various growth stages, vegetative and flower tissues) was designed and used for comprehensive investigation of gene expression before and during ripening (105 to 147 days after fu...
ORGANISM(S): Pyrus pyrifolia 
2010-10-12 | E-GEOD-18682 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of fruit flesh of European pear M-bM-^@M-^XLa FranceM-bM-^@M-^Y during fruit development
Comprehensive investigation of gene expression during fruit development and ripening in European pear (Pyrus communis). Gene expression of fruit flesh development of European pear was measured from -7 to 182 days after full bloom (DAFB). 150 DAFB is harvested stage and 182 DAFB is after ripening by ...
ORGANISM(S): Pyrus communis 
2013-12-18 | E-GEOD-48393 | biostudies-arrayexpress
TranscriptomicsComparison of pear M-bM-^@M-^XLa FranceM-bM-^@M-^Y and its bud mutant M-bM-^@M-^XGiant LafM-bM-^@M-^Y (2010 expt, receptacle at 1 week before full bloom stage)
Bud mutation (bud sport) is mutation occurred in one branch in a tree and the mutant branch shows different phenotype from normal branches. Because bud mutation occurs in a part of plant body, genomic backgrounds of mutant branch and normal branches are the same, except some mutations. Therefore bud...
ORGANISM(S): Pyrus communis 
2012-12-31 | E-GEOD-38550 | biostudies-arrayexpress
UnknownNational trends in the outcomes of subarachnoid haemorrhage and the prognostic influence of stroke centre capability in Japan: retrospective cohort study.
Not available
S-EPMC10111904 | biostudies-literature
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