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ProteomicsProteomic analysis of bone marrow cells from wild-type and Dcaf8 knockout mice
To explore the mechanisms by which DCAF8 deficiency induces functional defects in hematopoietic stem cells with an aging-like phenotype, and given DCAF8’s role as a substrate receptor in the E3 ubiquitin ligase complex, we conducted ubiquitin proteomic analysis on bone marrow cells from wild-type an...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-04 | PXD056221 | Pride
Dcaf8  bone marrow  aging 
ProteomicsUbiquitin proteomic analysis of bone marrow cells from wild-type and Dcaf8 knockout mice
To explore the mechanisms by which DCAF8 deficiency induces functional defects in hematopoietic stem cells with an aging-like phenotype, and given DCAF8’s role as a substrate receptor in the E3 ubiquitin ligase complex, we conducted ubiquitin proteomic analysis on bone marrow cells from wild-type an...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-04 | PXD056263 | Pride
Dcaf8  bone marrow  aging 
ProteomicsProteomic analysis of Lineage negative bone marrow cells from wild-type and Dcaf8 knockout mice
To explore the mechanisms by which DCAF8 deficiency induces functional defects in hematopoietic stem cells with an aging-like phenotype, and given DCAF8’s role as a substrate receptor in the E3 ubiquitin ligase complex, we conducted proteomic analysis on Lineage negative bone marrow cells from wild-...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-04 | PXD056107 | Pride
Aging Dcaf8 Bone marrow 
ProteomicsPharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis
Protein tyrosine phosphatase mitochondrial 1 (PTPMT1), is a member of the protein tyrosine phosphatase superfamily localized on the mitochondrial inner membrane, and regulates the biosynthesis of cardiolipin. Given the important position of PTPMT1 in mitochondrial function and metabolism, pharmacolo...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058606 | Pride
Ptpmt1  mitochondria  ferroptosis  tca cycle  hepatocellular carcinoma 
ProteomicsDeep metaproteomics of inflammatory bowel diseases
Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is associated with a loss or an imbalance of host-microbe interactions. Depletion-assisted deep metaproteomics was employed to reveal disease-specific networks of host-microbial protein associations in IBD...
ORGANISM(S): Homo Sapiens 
2023-06-28 | PXD043380 |
ProteomicsIntegrated Landscape of Plasma Metabolism and Proteome for Post-traumatic Deep Vein Thrombosisasma Metabolism and Proteome for Post-traumatic Deep Vein Thrombosis
Deep vein thrombosis (DVT) is a leading cause of morbidity and mortality after trauma. Here, we integrate metabolomics and proteomics in up to 680 individuals with and without DVT after trauma (pt-DVT) to reveal the metabolic alterations and their function, and provide potential biomarkers. We carri...
ORGANISM(S): Homo Sapiens 
2024-07-22 | PXD054131 |
ProteomicsStructural mass spectrometry captures residue-resolved comprehensive conformational rearrangements of a G protein-coupled receptor
GPCR structural studies with in-solution spectroscopic approaches have offered distinctive insights into GPCR activation and signaling that highly complement those yielded from structural snapshots by crystallography or cryo-EM. While most current spectroscopic approaches excel at probing structural...
ORGANISM(S): Homo Sapiens 
2024-04-26 | PXD048942 |
ProteomicsApolipoprotein E as a potential biomarker of moyamoya disease
The underlying mechanisms of moyamoya disease (MMD) remain unclear, and there is a lack of effective biomarkers. This study aimed to identify novel serum biomarkers of MMD.
ORGANISM(S): Homo Sapiens 
2023-02-08 | PXD039975 |
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