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ProteomicsIonizable polymeric micelles (IPMs) for efficient siRNA delivery
Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance. We design three ionizable oligo-mers (IOs) that, with PLA-PEG, form Ionizable Polymeric Micelles (IPMs), a potential siRNA delivery system, which can achie...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-21 | PXD057444 | Pride
Hsp47 Protein corona Hmgb1 Hepatic fibrosis Fibroblast activation protein inhibitor (fapi) Nucleic acid delivery Ionizable polymeric micelles (ipms) Hepatic stellate cells 
MetabolomicsLipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals

The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized. Liquid chromatography coupled to tandem mass spectromet...

2017-04-26 | MTBLS352 | MetaboLights
GenomicsGlobal Mapping of H3K4me1 and H3K4me3 in human CD4+CD25+FOXP3+ Treg cells
Regulatory T cells (Treg) contribute to the crucial immunological processes of self-tolerance and immune homeostasis. However, the mechanisms underlying Treg function and cell fate decisions to differentiate between Treg and conventional T cells (Tconv) remain to be fully elucidated, especially at t...
ORGANISM(S): Homo sapiens 
2011-01-31 | E-GEOD-26427 | biostudies-arrayexpress
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