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MetabolomicsDNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease (CKD). Herein, we found that the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) was significantly increased in the kidney tissues of both CKD...

2023-01-25 | MTBLS5971 | MetaboLights
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
ProteomicsUbiquitylation-omics analysis on WWP2 overexpressed mouse tubular epithelial cells (MPTCs)
WWP2 is a E3 ubiquitin ligase which may be implicated in multiple cellular event. WWP2 expressed in the kidneys and its pathological role remain to be elucidated. We performed this ubiquitylation omics analysis on renal tubular epithelial cells which overexpressd WWP2 to study WWP2's potential ubiqu...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD048540 | Pride
Renal tubular epithelial cells Ubiquitylation-omics 
ProteomicsQuantitative proteinomics on WWP2 overexpressed human tubular epithelial cells HK-2
WWP2 is a E3 ligase which regulates multiple cellular events, such as stress response, differentiation. WWP2 played physiological role in the distal tubules of the kidneys. Whether WWP2 regulated pathophysiological rol in the proximal tubules is unclear. In the present study, we stably overexpressed...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD048622 | Pride
Human tubular epithelial cells Wwp2 Proteinomics 
ProteomicsiTRAQ-Based Proteomics Analysis Revealed Proteins Involved in Drought Response During the Germination Stage in Faba Bean
iTRAQ-Based Proteomics Analysis Revealed Proteins Involved in Drought Response During the Germination Stage in Faba Bean
ORGANISM(S): Vicia Faba 
2023-11-17 | PXD047083 |
Proteomicsmass spectrometry analysis of in vitro kinase assay for DNA-PKcs and TAF7
To examine whether TAF7 could be phosphorylated by DNA-PKcs directly. An in vitro kinase assays were performed. Firstly, human DNA-PKcs was purified from TGF1 treated HK2 cells by immunoprecipitation with a DNA-PKcs antibody (abcam) and IgG was used as a negative control. The purified proteins and ...
ORGANISM(S): Homo Sapiens 
2022-09-22 | PXD036930 |
TranscriptomicsAn Easy Operating Pathogen Microarray (EOPM) Platform for Rapid Screening of Vertebrate Pathogens
An Easy Operating Pathogen Microarray (EOPM) was designed to detect almost all known pathogens and related species based on their genomic sequences. For effective identification of pathogens from EOPM data, a statistical enrichment algorithm has been proposed and further implemented in a user-friend...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-45860 | biostudies-arrayexpress
ProteomicsDNA-PK drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming
Phosphoproteomics profiling of WT and DNA-PKcs-/- mouse kidney tissues was performed to reveal possible substrates of DNA-PK
ORGANISM(S): Mus Musculus 
2022-01-06 | PXD030789 |
UnknownDeficiency of CAMSAP2 impairs olfaction and the morphogenesis of mitral cells
Not available
S-SCDT-10_1038-S44319-024-00166-X | biostudies-other
UnknownLONP1 Targets HMGCS2 to Protect Mitochondrial Function and Attenuate Chronic Kidney Disease
Not available
S-SCDT-10_15252-EMMM_202216581 | biostudies-other
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