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ProteomicsIdentification of the E3 ligase(s) recruited by 955 to degrade CDK9
PROTACs induce the degradation of target proteins by hijacking an E3 ligase. However, it is usually difficult to directly identify the E3 ligase recruited by a new E3 ligase ligand in a PROTAC using the co-immunoprecipitation method because the formation of the complex is transient and very dynamic....
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD039401 | Pride
Turboid Protac Pl Cdk9 E3 ligase 
ProteomicsPiperlongumine (PL) conjugates induce targeted protein degradation
PROteolysis Targeting Chimeras (PROTACs) are bifunctional molecules that degrade target proteins through recruiting E3 ligases. However, their application is limited in part because few E3 ligases can be recruited by known E3 ligase ligands. In this study, we identified piperlongumine (PL), a natura...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD039385 | Pride
Piperlongumine Protac E3 ligase Cdk9 
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