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ProteomicsHuamn colon cancer cell line SW480 proteome changes following Lappaol F treatment
Lappaol F, a natural lignin isolated from the seeds of Arctium lappa L., was previously shown to have an inhibitory effect on tumour cells and might be a promising drug candidate for cancer chemotherapy. In the present study, human colon cancer cell line SW480 was treated with Lappaol F, and quantit...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD017872 | Pride
Lappaol f  huamn colon cancer cell line sw480  differentially expressed proteins 
ProteomicsCyclin F - EXO1 axis controls cell cycle dependent execution of double strand break repair
Ubiquitination is a crucial post-translational modification required for the proper repair of DNA double-strand breaks (DSBs) induced by ionising radiation (IR). DSBs are mainly repaired through homologous recombination (HR) when template DNA is present and non-homologous end joining (NHEJ) in its a...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051841 | Pride
Microhomology-mediated end joining And cancer Ionising radiation Dna damage repair Dna damage response Dna double strand breaks Exo1 Ubiquitination Single strand annealing Cell cycle Cyclin f 
TranscriptomicsGenome Sequencing and Comparative Transcriptomics of Race1 and Race4 of Banana pathogen: Fusarium oxysporum f.sp. Cubense
Deep sequencing of mRNA from Fusarium oxysporum f. sp. Cubense 1 and 4 after infecting Musa acuminata 0h and 48h. Analysis of ploy(A)+ RNA of different hours after infecting of Musa acuminata
ORGANISM(S): Fusarium oxysporum f. cubense 
2014-08-27 | E-GEOD-40581 | biostudies-arrayexpress
ProteomicsPhosphorylation of Cyclin F at Serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(Cyclin F) complex.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and cachexia often resulting in patient death within 3-5 years of diagnosis. Recently, we identified mutations to the CCNF gene, which encodes the Cyclin F protein, in c...
ORGANISM(S): Homo sapiens (Human) 
2017-12-08 | PXD004531 | Pride
Als Phosphorylation Ubiquitylation E3 ligase 
ProteomicsALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ
Recently, we identified missense mutations in CCNF that are causative of familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). CCNF encodes for cyclin F, a substrate recognition component of an E3-ubiquitin ligase. Mutations in CCNF directly implicates disrupti...
ORGANISM(S): Homo sapiens (Human) 
2021-03-18 | PXD014163 | Pride
Bioid Ubiquitylation Proteomics Amyotrophic lateral sclerosis Frontotemporal dementia Paraspeckles Cyclin f Rbm14 Homeostasis 
ProteomicsComparative O-glycoproteomics of Fusarium oxysporum
Fusarium oxysporum causes Fusarium wilt syndrome in more than 120 different plant hosts, including globally important crops such as tomato, cotton, banana, melon, etc. F. oxysporum shows high host specificity in over 150 formae speciales and have been ranked in the top 10 plant fungal pathogens. Alt...
ORGANISM(S): Fusarium oxysporum f. cucumerinum 
2019-10-28 | PXD012530 | Pride
Fusarium oxysporum O-mannosylation Glycoproteomics Pmt Lc-ms/ms 
UnknownComprehensive analysis of amino acid sequence diversity at the F protein cleavage site of Newcastle disease virus in fusogenic activity.
Not available
S-EPMC5580908 | biostudies-literature
ProteomicsIdentification of the cellular component interacted with F. nucleatum.
We incubated F. nucleatum lysates with biotinylated proteins from KRAS p.G12D, KRAS p.G13D and KRAS WT cells respectively. Subsequent western blot analysis showed that three candidate proteins from F. nucleatum might interact with KRAS p.G12D cells. The bands of interest were then submitted for mass...
ORGANISM(S): Fusobacterium nucleatum CTI-1 
2024-01-25 | PXD048686 | Pride
Kras g12d fn1859 
UnknownExpression of recombinant allergen, Der f 1, Der f 2 and Der f 4 using baculovirus-insect cell systems.
Not available
S-EPMC6209719 | biostudies-literature
TranscriptomicsExpression analysis of Vibrio cholerae O395N1 delta-nqrA-F mutant
Investigation of whole genome gene expression level changes in a Vibrio cholerae O395N1 delta-nqrA-F mutant, compared to the wild-type strain. Total RNA recovered from wild-type cultures of VIbrio cholerae O395N1 and its nqrA-F mutant strain. Each chip measures the expression level of 3,835 genes f...
ORGANISM(S): Vibrio cholerae 
2014-04-01 | E-GEOD-56387 | biostudies-arrayexpress
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