Sort   by:  
 Page size 
ProteomicsCTDP1 and RPB7 Stabilize Pol II and Permit Reinitiation
The mechanisms governing the termination and subsequent reinitiation of RNA polymerase II (Pol II) remain poorly understood. Here we found that depletion of RPB7 leads to the destabilization of Pol II’s largest subunit, RPB1. This destabilization is influenced by the loop regions of RPB7, CDK9, the ...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-05 | PXD048909 | Pride
Label-free ms Ctdp1 Rpb7 Rpb1-turboid 
ProteomicsKK-LC-1 as a feasible therapeutic target to eliminate ALDH+ stem cells in triple negative breast cancer
Failure to achieve complete elimination of triple negative breast cancer (TNBC) stem cells after adjuvant therapy is associated with poor outcomes. Aldehyde dehydrogenase 1 (ALDH1) is a marker of breast cancer stem cells (BCSCs), and its enzymatic activity regulates tumor stemness. Identifying upstr...
ORGANISM(S): Homo sapiens (Human) 
2023-04-12 | PXD040200 | Pride
Cancer stem cell Tnbc Hippo signaling pathway Aldh+ stemness Protein-protein inhibitor. 
Proteomics4D label-free quantitative proteomics analysis of collagen-induced arthritis rats
4D label-free quantitative proteomics was performed to analysis the changes of protein expression in synovial tissues between Normal control group, Model control group and JTQBG treated group.
ORGANISM(S): Rattus Norvegicus 
2024-02-23 | PXD050056 |
Sort   by:  
 Page size