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ProteomicsSILAC of hESCs with DDX18 knockdown
This study explores the crucial role of the nucleolus-specific RNA helicase DDX18 in maintaining the pluripotency of human embryonic stem cells. We demonstrate that DDX18 coordinates nucleolus phase separation and chromatin organization by interacting with NPM1 in the granular component of the nucle...
ORGANISM(S): Homo sapiens (Human) 
2024-11-18 | PXD057813 | Pride
Knockdown Ddx18 Silac 
ProteomicseIF4A3 interactome by IP-MS in mouse ESCs
RNA helicases are involved in multiple steps of RNA metabolism to direct their roles in gene expression, yet their functions in pluripotency control remain largely unexplored. Starting from an RNAi screen of RNA helicases, we identified that eIF4A3, a DEAD-box (Ddx) helicase component of the exon ju...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD031362 | Pride
Ip-ms Eif4a3 Escs 
ProteomicsOCT4 IP-MS in Naive and Primed Human ESCs
Understanding the molecular underpinnings of pluripotency is a prerequisite for optimal maintenance and application of embryonic stem cells (ESCs). While the protein-protein interactions of core pluripotency factors have been identified in mouse ESCs, their interactome in human ESCs (hESCs) has not ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-12 | PXD026556 | Pride
Oct4 Esc 
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