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ProteomicsIntegrative Proteome and Lysine Acetylation Analyses of Subcutaneous and Visceral Adipose Tissues in People with Metabolically Unhealthy Obesity
Adipose tissue is critical in the development of Metabolically unhealthy obesity (MUO). This study aimed to investigate the different responses and regulations of subcutaneous (SA) and visceral adipose tissue (VA) to MUO by integrative proteome and lysine acetylation (Kac) analyses. This study signi...
ORGANISM(S): Homo Sapiens 
PXD056800 |
ProteomicsGlobal Analysis of Lysine Acetylation in the Brain Cortex of K18-hACE2 Mice Infected with SARS-CoV-2
In order to research the relationship between neurological sequelae of COVID-19 and acetylation of brain cortexes, we reported for the first time the acetylome in the brain cortex of the K18-hACE2 infected mouse model, and the difference between the SARS-CoV-2 infection group and the control group, ...
ORGANISM(S): Mus Musculus 
PXD036853 |
ProteomicsSerum metabolomics reveal metabolic changes in coal workers’ pneumoconiosis progression
The raw data of coal workers pneumoconiosis serum metabolomics
ORGANISM(S): Homo Sapiens 
PXD068448 |
ProteomicsPreconception COVID-19 Vaccination Reprograms Fetal Metabolism to Accelerate Intrauterine Recovery and Suppress Persistent Metabolic Memory
The LC-MS/MS raw data from negative mode of umbilical cord blood from pregnant women
ORGANISM(S): Homo Sapiens 
PXD078591 |
ProteomicsProteomic and phosphoproteomic profiling of original, Delta, or Omicron strain SARS-CoV-2-infected lung of rhesus macaque
The Omicron variant, mutated from the original SARS-CoV-2 strain, is still circulating worldwide. We performed LC-MS based proteome and phosphoproteome analysis using lung tissues separated from rhesus monkeys, which were infected with Omicron, the original virus or one of the VOCs, the Delta varian...
ORGANISM(S): Macaca Mulatta 
2023-12-12 | PXD047779 |
ProteomicsGlobal profiling of the proteome and acetylome in mice with abdominal aortic aneurysms
Abdominal Aortic Aneurysm (AAA) is a fatal vascular disease characterized by abnormal expansion of the arterial wall and a high risk of rupture. Current treatments for AAA primarily rely on surgical intervention, while effective pharmacological therapies have yet to be developed. The major bottlenec...
ORGANISM(S): Mus Musculus 
2025-02-17 | PXD060895 |
ProteomicsA comprehensive proteome and phosphoproteome atlas across nine organs of the Chinese hamster
We present the first comprehensive proteomic and phosphoproteomic atlas of nine major organs of the Chinese hamster (Cricetulus griseus). A total of 14,219 proteins, 11,828 phosphorylated proteins, and 47,122 phosphorylation sites were identified, revealing distinct inter-organ molecular features.
ORGANISM(S): Cricetulus Griseus 
PXD069241 |
ProteomicsMulti-organ Proteomic and Phosphoproteomic Profiles of Mpox Virus Infection in SIVmac239-infected Rhesus Macaques
Macaque study was conducted in an ABSL-3 facility, adhering to protocols approved by the Institutional Animal Care and Use Committee (IACUC) under the guidelines of the Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (Approval Number XJ23004). All animals were single-hous...
ORGANISM(S): Macaca Mulatta 
PXD056753 |
ProteomicsProteome, lysine acetylome and succinylome identify post-translational modification of STAT1 as a novel drug target in silicosis
Inhalation of crystalline silica dust induces incurable lung damage, silicosis and pulmonary fibrosis. However, the mechanisms of the lung injury remain poorly understood, with limited therapeutic options aside from lung transplantation. Post-translational modifications can regulate the function of...
ORGANISM(S): Mus Musculus 
2024-02-04 | PXD049146 |
ProteomicsProteomic analysis of 442 clinical plasma samples from healthy donors and COVID-19 covalescent patients
In this study, we collected plasma samples from 22 healthy controls (HC group), 43 hospitalized patients (HO group), 196 convalescent patients 6 months after COVID-19 infection (first follow-up, F1 group), and 181 convalescent patients 12 months after COVID-19 infection (second follow-up, F2 group)....
ORGANISM(S): Homo Sapiens 
PXD054533 |
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