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ProteomicsA Bifunctional SPD-0090 contributes virulence of Streptococcus pneumoniae by affecting iron transport and galactose metabolism
Streptococcus pneumoniae (S.pneumoniae) is a Gram-positive bacterial pathogen that colonizes on the mucosal surfaces of the host's nasopharynx and upper respiratory tract and results in pneumonia. In order to survive and infect the host, S.pneumoniae must have obtain essential nutrients, such as tra...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2022-06-01 | PXD030183 | Pride
Spd-0090 Virulence Iron transport protein Galactose metabolism Streptococcus pneumoniae 
ProteomicsProteomics analysis of white adipose tissue in high fat diet fed mice
The popularity of high fat foods in modern society has been associated with epidemic of various metabolic diseases characterized by insulin resistance, the pathology of which involves complex interactions between multiple tissues such as liver, skeletal muscle and white adipose tissue (WAT). To unco...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD021019 | Pride
Insulin resistance  high fat diet  multi-tissue analysis 
ProteomicsQuantitative proteomic analysis of oxaliplatin induced peripheral neurotoxicity
We performed a data independent acquisition (DIA) -based quantitative proteomics strategy to investigate the global proteome alteration in the dorsal root ganglion (DRG) tissues from mice injected with oxaliplatin for different periods.
ORGANISM(S): Mus musculus (Mouse) 
2022-07-11 | PXD031322 | Pride
Metabolism Peripheral neurotoxicity Oxaliplatin Ros Quantitative proteomics 
ProteomicsProteomics analysis of insulin sensitive tissues in high fat diet fed mice
The popularity of high fat foods in modern society has been associated with epidemic of various metabolic diseases characterized by insulin resistance, the pathology of which involves complex interactions between multiple tissues such as liver, skeletal muscle and white adipose tissue (WAT). To unco...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-26 | PXD021046 | Pride
Insulin resistance  high fat diet  multi-tissue analysis 
UnknownThe role of metabolic memory in diabetic kidney disease: identification of key genes and therapeutic targets.
Not available
S-EPMC11292736 | biostudies-literature
ProteomicsGLP-1RA Ameliorates Polycystic Ovary Syndrome via Hypothalamic RASA1/AKT: A Novel pathway Linking Hyperandrogenism to GnRH Dysregulation
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenemia and hypothalamic-pituitary-gonadal (HPG) axis dysregulation involving gonadotropin-releasing hormone (GnRH) hyperactivity. While glucagon-like peptide-1 receptor agonists (GLP-1RAs) show therapeutic promise in PCOS, their central...
ORGANISM(S): Rattus Norvegicus 
PXD064291 |
UnknownpH-Triggered Sheddable Shielding System for Polycationic Gene Carriers.
Not available
S-EPMC6432142 | biostudies-literature
ProteomicsQuantitative proteomic analysis of experimental autoimmune encephalomyelitis mice implicates SUMOylation in multiple sclerosis
In this study, we performed quantitative proteomics utilizing a data-independent acquisition (DIA) strategy to investigate the proteome alteration in the brain and spinal cord tissues from mice with experimental autoimmune encephalomyelitis (EAE), a widely-used model for MS.
ORGANISM(S): Mus Musculus 
2024-03-20 | PXD050789 |
ProteomicsSlc44a2 deficiency unveils an IFN-I–dependent feedback control of pDC egress
This project aims to characterize the proteomic landscape of bone marrow-derived plasmacytoid dendritic cells (pDCs) from wild-type (WT) and Slc44a2-deficient (cKO) mice.
ORGANISM(S): Mus Musculus 
PXD076360 |
ProteomicsIdentification of p72-interacting proteins in porcine alveolar macrophages
To explore the potential mechanisms regulating p72 stability, we performed co-immunoprecipitation using an anti-p72 antibody in ASFV-infected PAMs, followed by mass spectrometry analysis to identify host factors interacting with p72.
ORGANISM(S): Sus Scrofa Domesticus 
2026-01-18 | PXD073232 |
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