Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of human heat shocked HeLa cell line with siRNA knockdown of HSF1
Although HSF1 is known to play an important role in regulating the cellular response to proteotoxic stressors, little is known about the structure and function of the HSF1 signaling network under both stressed and unstressed conditions. In this study, we used a combination of chromatin immunoprecip...
ORGANISM(S): Homo sapiens 
2007-06-22 | E-GEOD-3697 | biostudies-arrayexpress
TranscriptomicsTemporal Concordance between Apical and Transcriptional Points-of-Departure for Chemical Risk Assessment
The number of legacy chemicals without toxicity reference values combined with the rate of new chemical development are overwhelming the capacity of the traditional risk assessment paradigm. More efficient approaches are needed to quantitatively estimate chemical risks. In this study, rats were do...
ORGANISM(S): Rattus norvegicus 
2013-04-22 | E-GEOD-45892 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of rat testis following combined fetal and postnatal DBP exposure
Provided later Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in ...
ORGANISM(S): Rattus norvegicus 
2008-11-24 | E-GEOD-13550 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Dose Response Changes in Female Mouse and Rat Lungs following Chloroprene Exposure
ß-chloroprene (2-chloro-1,3-butadiene), a monomer used in the production of neoprene elastomers, is of regulatory interest due to the production of multi-organ tumors in mouse and rat cancer bioassays. A significant increase in female mouse lung tumors was observed at the lowest exposure concentrat...
ORGANISM(S): Rattus norvegicus 
2012-10-12 | E-GEOD-40795 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of the response of Rattus norvegicus nasal epithelial cells to treatment with various doses of formaldehyde
Formaldehyde, an important industrial chemical, is used for multiple commercial purposes throughout the industrialized world. This simple, one carbon aldehyde is a natural metabolite formed in cells throughput the body. However, it is also a rodent nasal carcinogen, when inhaled by rats every day ...
ORGANISM(S): Rattus norvegicus 
2007-10-25 | E-GEOD-7002 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat female mouse lung tumors in rodent cancer bioassays - a 13 chemical training set
The primary goal of toxicology and safety testing is to identify agents that have the potential to cause adverse effects in humans. Unfortunately, many of these tests have not changed significantly in the past 30 years and most are inefficient, costly, and rely heavily on the use of animals. The r...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6116 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver treated with carcinogens and controls to identify biomarkers
Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures ...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-5128 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung treated with carcinogens and controls to evaluate carcinogenicity and identify biomarkers
Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures ...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-5127 | biostudies-arrayexpress
Sort   by:  
 Page size