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ProteomicsIdentification of Glycoproteins Associated with HIV Latently Infected Cells Using Quantitative Glycoproteomics
HIV infection is not curable due to viral latency. Compelling reports studying proteins such as CD2, PD-1, LAG-3 and TIGIT suggest that there is a distinct profile of surface proteins that can be used for targeting latently infected cells. We have recently reported that glycoproteins were differenti...
ORGANISM(S): Homo sapiens (Human) 
2016-05-23 | PXD003561 | Pride
Latency Hiv Speg Quantitative glycoproteomics 
ProteomicsSite-specific Extraction of O-linked glycopeptides (EXoO) Maps Landscape of In Vivo O-linked Glycoproteome
Protein glycosylation is one of the most common protein modifications and plays essential roles in biology and therapeutics. However, the analysis of in vivo O-linked glycosylation, a major type of protein glycosylation, has been severely impeded by the scarcity of technology. Here, a chemoenzymatic...
ORGANISM(S): Homo sapiens (Human) 
2018-12-05 | PXD009476 | Pride
Site-specific Glycosylation Exoo In vivo O-linked 
ProteomicsComparison of Intact Glycopeptide Enrichment Methods Using Strong Anion Exchange and Hydrophilic Interaction Liquid Chromatography
Heterogeneity of protein glycosylation poses great challenge for analysis that is key to un-puzzle systems glycobiology in diseases. Resolving this conundrum requires global enrichment of glycopeptides for identification and quantitation. To this aim, hydrophilic interaction chromatography (HILIC) h...
ORGANISM(S): Homo sapiens (Human) 
2017-10-19 | PXD005145 | Pride
Glycoproteomics Hilic Sax Quantitation O-linked 
ProteomicsEXoO-Tn: Tag-n-Map the Tn Antigen in the Human Proteome
Tn antigen (Tn), a single N-acetylgalactosamine (GalNAc) monosaccharide attached to protein Ser and Thr residues, is found on most solid tumors yet rarely detected in adult tissues: featuring it one of the most distinctive signatures of cancers. Although it is prevalent in cancers, Tn-glycosylation ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD014390 | Pride
Tn antigen Glycoproteomics O-galnac Exoo-tn 
ProteomicsIdentification of novel glycoproteins expressed on human macrophage surface using glycoproteomics
Prostate cancer is a leading cause of cancer-related deaths of men in the U.S. While localized disease is highly treatable by surgical resection and radiation, cancer that has metastasized remains incurable. Immune cells that primarily scavenge debris, promote prostate cancer angiogenesis and woun...
ORGANISM(S): Homo sapiens (Human) 
2017-03-31 | PXD005080 | Pride
Macrophage glycoproteome Glycoproteomics Prostate cancer Human 
ProteomicsAn unusual dual sugar-binding lectin domain controls the substrate specificity of a mucin-type O-glycosyltransferase
N-acetylgalactosaminyl transferases (GalNAc-Ts) initiate mucin-type O-glycosylation, an abundant and complex post-translational modification that regulates host-microbe interactions, tissue development, and metabolism. GalNAc-Ts contain a C-terminal lectin domain consisting of three homologous repea...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD047845 | Pride
Muc1 O-glycosylation Structure Lectin domain Substrate specificity 
ProteomicsQuantitative Mapping of the in vivo O-GalNAc Glycoproteome in Mouse Tissues
A large family of GalNAc transferases (GalNAc-Ts) catalyzes the covalent attachment of N-Acetylgalactosamine (GalNAc) to serine and threonine residues on proteins that pass through the secretory pathway in the first committed step of mucin-type O-glycosylation. Abnormalities in the activity of indi...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD040196 | Pride
O-galnac Site-specific Glycoproteome Mouse tissues 
ProteomicsDetection of Aggressive Prostate Cancer-Associated Glycoproteins in Urine using Glycoproteomics and Mass Spectrometry
Clinical management of prostate cancer remains a significant challenge due to the lack of available tests for guiding treatment decisions. The blood Prostate-Specific Antigen (PSA) test has facilitated early detection and intervention of prostate cancer. However, blood PSA levels are less effective ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD004495 | Pride
Prostate cancer/aggressive/glycoprotein/urine/mass spectrometry-lc-ms/ms/ biomarkers/ body fluids 
ProteomicsSite-specific Analysis of O-linked Glycoproteome Using Chemoenzymatic Strategy, part 2
Protein glycosylation is ubiquitous and plays critical roles in biology. However, study of O-linked glycoproteome (O-glycoproteome), a major type of protein glycosylation, has been severely impeded due to paucity of technology. We presented a chemoenzymatic strategy for extraction of site-specific O...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD007895 | Pride
Site specific O-linked glycoproteomics Hiv Solid phase 
ProteomicsComparison of Intact Glycopeptide Enrichment Methods Using Strong Anion Exchange and Hydrophilic Interaction Liquid Chromatography
Heterogeneity of protein glycosylation poses great challenge for analysis that is key to un-puzzle systems glycobiology in diseases. Resolving this conundrum requires global enrichment of glycopeptides for identification and quantitation. To this aim, hydrophilic interaction chromatography (HILIC) h...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-02 | MSV000082566 | MassIVE
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