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MetabolomicsShort-Term Clinical Response and Changes in the Fecal Microbiota and Metabolite Levels in Patients with Crohn's Disease After Stem Cell Infusions
Recent studies have shown a close relationship between the gut microbiota and Crohn's disease (CD). This study aimed to determine whether mesenchymal stem cell (MSC) treatment alters the gut microbiota and fecal metabolite pathways and to establish the relationship between the gut microbiota and fec...
2025-07-03 | MTBLS6288 | MetaboLights
UnknownEvolutionary Trend Analysis of Research on 5-ALA Delivery and Theranostic Applications Based on a Scientometrics Study.
Not available
S-EPMC9320574 | biostudies-literature
ProteomicsMulti-organ Proteomic and Phosphoproteomic Profiles of Mpox Virus Infection in SIVmac239-infected Rhesus Macaques
Macaque study was conducted in an ABSL-3 facility, adhering to protocols approved by the Institutional Animal Care and Use Committee (IACUC) under the guidelines of the Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (Approval Number XJ23004). All animals were single-hous...
ORGANISM(S): Macaca Mulatta 
2024-10-12 | PXD056753 |
ProteomicsExploring the Anti-Cancer mechanism of Cardiac Glycosides using proteome integral solubility alteration approach
Cancer remains a significant global health challenge, necessitating the development of innovative and cost-effective treatments. Drug repurposing, particularly of cardiac glycosides (CGs), offers a promising strategy to expedite the discovery of anti-tumor drugs. This study employs proteome integral...
ORGANISM(S): Homo Sapiens 
2024-05-31 | PXD052740 |
ProteomicsCanagliflozin ameliorates progestin resistance by suppressing RARβ/CRABP2 signaling in TRβ knockout endometrial cancer cells
THRB-knockout RL95-2 (THRB(-/-)/RL95-2) cells were constructed to investigate progestin resistance mechanisms. Cell proliferation and apoptosis were assessed in RL95-2 and THRB(-/-)/RL95-2 cells treated with canagliflozin (CANA), medroxyprogesterone acetate (MPA), or their combination using CCK-8, E...
ORGANISM(S): Homo Sapiens 
2025-02-07 | PXD060591 |
ProteomicsSimultaneous profiling of phosphorylation and S-nitrosylation during maize seed germination
We developed a phosphate-affinity tag-switch (PAT-switch) proteomics workflow enabling simultaneous, site-specific profiling of phosphorylation and S-nitrosylation during maize seed germination.
ORGANISM(S): Zea Mays 
2026-01-21 | PXD073327 |
ProteomicsProteomic analysis of COVID-19 infection at early stage
We collected 14 patients who tested positive for nasopharyngeal swab real-time PCR for COVID-19 infections, in mild to moderate stage, among which are 6 males and 8 females with ages ranging from 30 to 77. The two control groups were 13 non-COVID-19 pneumonia patients and 10 healthy people. Then we ...
ORGANISM(S): Homo Sapiens 
2020-07-23 | PXD020522 |
ProteomicsIdentification and sequencing of CD36 interacting proteins in cardiomyocytes
Identification and sequencing of CD36 interacting proteins in cardiomyocytes
ORGANISM(S): Mus Musculus 
2024-10-11 | PXD056711 |
ProteomicsCleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy
Metabolic heterogeneity resulting from the intrinsic heterogeneity of human tumors has been shown to cause a myriad of adverse outcomes of tumor therapy, including resistance to chemotherapy, but the mechanisms inside remain largely unknown. Here, we found that the de novo pyrimidine synthesis pathw...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059365 |
ProteomicsTargeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers
Despite advances in the development of direct KRAS inhibitors, KRAS-mutant cancers continue to exhibit resistance to the currently available therapies. Here, we identified REGγ as a mutant KRAS-associated factor that enhances REGγ transcription through the KRAS intermediate NRF2, suggesting that the...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059364 |
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