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ProteomicsPhage depolymerase modulates virulence and biofilm in hypervirulent Klebsiella pneumoniae by CPS-mediated suppression of type 3 fimbriae
Phage-derived depolymerases represent a promising antibiotic alternative for treating Klebsiella pneumoniae infections. Depolymerases can increase the sensitivity of bacteria to the host immune system and complement-mediated killing by specifically degrading capsular polysaccharides (CPS). However, ...
ORGANISM(S): Homo sapiens (Human) Klebsiella pneumoniae 
2026-06-28 | PXD080233 | Pride
Klebsiella pneumoniae  capsular polysaccharides  type 3 fimbriae  depolymerase  virulence  biofilm 
MetabolomicsPhosphoproteomic and Metabolomic Profiling Uncovers the Roles of CcPmk1 in the Pathogenicity of Cytospora chrysosperma

Pmk1, a highly conserved pathogenicity-related mitogen-activated protein kinase (MAPK) in pathogenic fungi, is phosphorylated and activated by MAP2K and acts as a global regulator of fungal infection and invasive growth by modulating downstream targets. However, the hierarchical CcPmk1 regulatory...

2022-07-11 | MTBLS4463 | MetaboLights
ProteomicsTMT-based Multiplexed (Chemo)proteomics on the Orbitrap Astral Mass Spectrometer
This dataset contains an evaluation of TMT-based multiplexed proteomics on the Orbitrap Astral mass spectrometer.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-12-17 | MSV000096674 | MassIVE
ProteomicsMegavirus Translation Initiation Factor 4A Plays an Important Role in the Regulation of Viral and Host Protein Translation and Host Adaptation
The presence of translation-related proteins has long been seen as a critical distinction between viruses and cellular life, the discovery of giant viruses has challenged this standard. We prove that the potential eukaryotic translation initiation factor 4A (eIF4A, Mb0671) encoded by the Megavirus b...
ORGANISM(S): Mimivirus Sp. Sh 
2024-10-03 | PXD056594 |
ProteomicsHistone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting
To look for factors that may have preferential binding to H3S28ph and mediate the stimulation to gene expression.
ORGANISM(S): Mus Musculus 
2022-05-25 | PXD034125 |
ProteomicsMosaic PKHD1 variants in polycystic kidney caused aberrant protein profiling of mitochondria and lysosomes
Autosomal recessive polycystic kidney disease (ARPKD) is a severe renal cystic disease mainly caused by PKHD1. However, its genetic cause, pathological features, and mechanism remained unsolved. Our findings may provide new insight on the pathophysiology of the polycystic kidney due to PKHD1 deficie...
ORGANISM(S): Homo Sapiens 
2021-08-20 | PXD028042 |
ProteomicsSlc44a2 deficiency unveils an IFN-I–dependent feedback control of pDC egress
This project aims to characterize the proteomic landscape of bone marrow-derived plasmacytoid dendritic cells (pDCs) from wild-type (WT) and Slc44a2-deficient (cKO) mice.
ORGANISM(S): Mus Musculus 
2026-03-31 | PXD076360 |
ProteomicsThe proteome data of human mesenchymal stem cell derived from healthy donors
The protein samples stored at -80 °C were thawed and treated with lysis buffer (8M urea, 1% protease inhibitor, 50mM NH4HCO3) for 5 minutes in room temperature. After ultrasonic cracking on ice and centrifugation at 14000g for 10 min at 20 °C, the amount of total protein of each MSC sample was detec...
ORGANISM(S): Homo Sapiens 
2023-06-12 | PXD033812 |
ProteomicsThe proteome data of extracellular vesicles derived from human umbilical cord and bone marrow mesenchymal stem cells
The protein samples stored at -80 °C were thawed and treated with lysis buffer (8M urea, 1% protease inhibitor, 50mM NH4HCO3) for 5 minutes in room temperature. After ultrasonic cracking on ice and centrifugation at 14000g for 10 min at 20 °C, the amount of total protein of each MSC sample was detec...
ORGANISM(S): Homo Sapiens 
2023-06-12 | PXD042977 |
UnknownPrevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study.
Not available
S-EPMC7880913 | biostudies-literature
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