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GenomicsBase-resolution methylation patterns accurately predict transcription factor bindings in vivo
Detecting in vivo transcription factor (TF) binding is important for understanding gene regulatory circuitries. ChIP-seq is a powerful technique to empirically define TF binding in vivo. However, the multitude of distinct TFs makes genome-wide profiling for them all labor-intensive and costly. Algor...
ORGANISM(S): Mus musculus 
2015-03-02 | E-GEOD-65093 | biostudies-arrayexpress
ProteomicsI.e. mouse ovary palmitoylation protein LC-MSMS
To identify a role for protein palmitoylation in ovarian of DHEA-induced PCOS mice model. First, we used DHEA to induce a PCOS mice model，hematoxylin-eosin (H&E) staining sections form the ovaries of the Control and DHEA groups.The mice oral gavage with DHEA disrupted ovarian morphology,the estrous ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD028835 | Pride
I.e. mouse ovary， palmitoylation protein， lc-msms 
ProteomicsMouse sertoli cells Palmitoylated protein MS
Elevated palmitic acid, a most abundant saturated fatty acid, is a risk factor for obesity complications. Here, we report that palmitic acid impairs spermatogenesis by inducing abnormal palmitoylation in Sertoli cells. Firstly, we proposed a correlation between palmitic acid and spermatogenesis by r...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD028778 | Pride
Mouse Ms Sertoli cells Palmitoylated protein 
UnknownChiglitazar diminishes the warburg effect through PPARγ/mTOR/PKM2 and increases the sensitivity of imatinib in chronic myeloid leukemia.
Not available
S-EPMC11657277 | biostudies-literature
ProteomicsProteomic data of ovary of OHSS model rat
The mass spectrometer was used to identify the labeled samples from electroacupuncture treated and Ovarian Hyper-stimulation Syndrome (OHSS) group. The ovarian proteins from four biological replicates in each group were extracted using the phenolic extraction method, iTRAQ labeling and quantitative ...
ORGANISM(S): Rattus Rattus 
2021-01-10 | PXD023493 |
ProteomicsOrbitrap Velos: narrow-range, defined mixtures for quantitative proteomics (PubMed ID: 23879310)
These five Orbi Velos replicates of samples A and B represent 36 proteins from the Sigma UPS1 that have been mixed in defined concentrations that span a narrow dynamic range. These "NRD A" and "NRD B" mixtures have, in turn, been spiked into Agilent Pyrococcus furiosus lysate.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Pyrococcus Furiosus (ncbitaxon:2261) 
2014-01-10 | MSV000078521 | MassIVE
ProteomicsOrbitrap: narrow-range, defined mixtures for quantitative proteomics (PubMed ID: 23879310)
These six Orbi replicates of samples A and B represent 36 proteins from the Sigma UPS1 that have been mixed in defined concentrations that span a narrow dynamic range. These "NRD A" and "NRD B" mixtures have, in turn, been spiked into Agilent Pyrococcus furiosus lysate.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Pyrococcus Furiosus (ncbitaxon:2261) 
2014-01-10 | MSV000078522 | MassIVE
GenomicsGenome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder in which patients carry premutation alleles of 55-200 CGG repeats on the FMR1 gene. To date, whether alterations in epigenetic regulation modulate FXTAS has gone unexplored. 5-hydroxymethylcytosine (5hmC) ...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49463 | biostudies-arrayexpress
GenomicsLin28A binds active promoters and recruits Tet1 to regulate gene expression
Lin28, a well-known RNA-binding protein, regulates diverse cellular properties. All physiological functions of Lin28A characterized so far have been attributed to its repression of let-7 miRNA biogenesis or modulation of the mRNA translational efficiency. Here we show that Lin28A directly binds to a...
ORGANISM(S): Mus musculus 
2015-12-07 | E-GEOD-74254 | biostudies-arrayexpress
GenomicsEnvironmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus
Gene-environment interactions mediated at the epigenetic level may provide an initial step in delivering an appropriate response to environmental changes. 5-hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC), accounts for ~40% of modified cytosine in brain and has been impl...
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-61194 | biostudies-arrayexpress
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