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ProteomicsIdentical Tumor Antigen Peptides by Canine and Human MHC Class I
Arobust immunopeptidomics workflow was developed to purify DLA_bound peptides from canine tumors and DLA-transduced monoallelic cell lines. This method was used to characterize the peptide repertoire and peptide binding motif of multiple DLA class I molecules
ORGANISM(S): Homo sapiens (Human) Canis familiaris (Dog) (Canis lupus familiaris) 
2026-04-22 | PXD074485 | Pride
Lc-msms Dog leukocyte antigen Immunopeptidomics Tumor 
ProteomicsMachine learning reveals limited contribution of trans-only encoded variants to the HLA-DQ immunopeptidome
HLA-DQ molecules can be formed as both cis and trans variants. So far, the progress for predicting HLA-DQ antigen presentation has been limited. In addition, the contribution of trans-only variants in shaping the HLA-DQ immunopeptidome remains largely unresolved. Here, we address these issues by int...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040860 | Pride
Machine learning Immunopeptidome Hla-dq 
ProteomicsAccurate prediction of antigen presentation for HLA class II across loci using tailored data acquisition and refined machine learning
Accurate prediction of antigen presentation by Human Leukocyte Antigen (HLA) class II molecules is crucial for rational development of immunotherapies and vaccines targeting CD4 T cell activation. So far, most prediction methods for HLA class II antigen presentation have focused on HLA-DR due to lim...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD044810 | Pride
Hla-class ii Netmhciipan-4.3 Antigen presentation Machine learning Hla-dp 
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