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TranscriptomicsExpression data from virus-specific mouse Th1 and Tfh CD4 T cell subsets after LCMV infection
CD4 T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for longlived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh lineage after antigen clearance. Using adoptive transf...
ORGANISM(S): Mus musculus 
2013-04-22 | E-GEOD-43863 | biostudies-arrayexpress
TranscriptomicsHuman regulatory T cells induce lymphocyte senescence
Analysis of gene alternations during the process of senescence induced by human regulatory T cells at various time points. Total RNA obtained from isolated regulatory T (Treg) cell-treated responder CD8+ T cells compared to the untreated T cells
ORGANISM(S): Homo sapiens 
2012-10-03 | E-GEOD-38765 | biostudies-arrayexpress
TranscriptomicsTemporal expression of miR-17-92a regulates effector and memory CD8+ T cell differentiation
This SuperSeries is composed of the following subset Series: GSE34216: miRNA signatures of antigen specific CD8+ T cells at different stages of immune response to LCMV infection GSE34217: Expression profile of miR-17-92a-MSCV-IRES-Thy1.1 transduced P14 CD8+ T cells Refer to individual Series
ORGANISM(S): Mus musculus 
2012-06-04 | E-GEOD-34218 | biostudies-arrayexpress
ProteomicsPhosphoproteomic analysis of T cell receptor stimulation-induced changes in human primary CD4+CD25- T cells in the absence or presence of regulatory T cells.
Regulatory T cells (Tregs) suppress other immune cells and are indispensable for human health, yet the molecular mechanisms of suppression remain incompletely understood. Tregs can suppress proliferation and cytokine production of CD4+CD25- conventional T cells (Tcons). We previously demonstrated th...
ORGANISM(S): Homo sapiens (Human) 
2017-08-28 | PXD004291 | Pride
Co-cultures Regulatory t cells (tregs) Ti-imac Human cd4+ t cells Phosphoproteomics 
TranscriptomicsExpression profile of miR-17-92a-MSCV-IRES-Thy1.1 transduced P14 CD8+ T cells
During acute viral infections, effector CD8+ T cells differentiate into memory precursors or short-lived terminal effectors. miR-17-92a over-expression skews CD8+ effector cells to the terminal differentiation. We used microarray to identify the genes that are differentially expressed caused by miR-...
ORGANISM(S): Mus musculus 
2012-06-04 | E-GEOD-34217 | biostudies-arrayexpress
ProteomicsProteome profile of Traf6-OE OT-I T cells
Proteome profile of Traf6-OE OT-I T cells and EV OT-I cells after viral transfection
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD039327 | Pride
Mouse Lc-ms Traf6-oe ot-i t cells 
TranscriptomicsmiRNA signatures of antigen specific CD8+ T cells at different stages of immune response to LCMV infection
miRNAs play an important role in regulating CD8+ T cell response. We used the microarray approach to profile the miRNA signatures of naïve, day 5 effector, day 8 effector, and memory CD8+ T cells. We identified a miRNA signature associated with rapidly proliferating effector CD8+ T cells. CD8+ T cel...
ORGANISM(S): Mus musculus 
2012-06-04 | E-GEOD-34216 | biostudies-arrayexpress
TranscriptomicsConserved non-coding sequence 2 (CNS2) of the Foxp3 genomic locus is essential for the function and stability of regulatory T cells during their activation
Regulatory T (Treg) cells play an indispensable role in immune homeostasis. The development and function of Tregs are dependent on transcriptional factor Foxp3, but how constant expression of Foxp3 is maintained in Tregs is not clear. Here we show that ablation of the conserved non-coding DNA seque...
ORGANISM(S): Mus musculus 
2014-09-04 | E-GEOD-57272 | biostudies-arrayexpress
TranscriptomicsAlternative Capture of Noncoding RNAs or Protein-Coding Genes by Herpesviruses to Alter Host T-Cell Function
In marmoset T cells transformed by Herpesvirus saimiri (HVS), a viral U-rich noncoding RNA, HSUR 1, specifically mediates degradation of host microRNA-27 (miR-27). High-throughput sequencing of RNA after crosslinking immunoprecipitation (HITS-CLIP) identified mRNAs targeted by miR-27 as enriched in ...
ORGANISM(S): Callithrix jacchus 
2014-09-01 | E-GEOD-55185 | biostudies-arrayexpress
ProteomicsAMBRA1 controls the translation of immune-specific genes in T lymphocytes
T cell receptor (TCR) engagement causes a global cellular response that entrains signaling pathways, cell cycle regulation, and cell death. The molecular regulation of mRNA translation in these processes is poorly understood. During a whole-genome CRISPR screen for regulators of CD95 (Fas/APO-1)-med...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-08 | MSV000096042 | MassIVE
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