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ProteomicsDistinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress - Data Set5: TMT dataset of aggregates in mitochondria
Mitochondria consist of hundreds of proteins, most of which are long-lived and inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions is poorly understood. Here we show that mitochondria form spatially defin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-26 | PXD048691 | Pride
Mitochondria aggregates 
ProteomicsDistinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress - Data Set4: Total proteome of NTS-VAR1 expressing yeast cells
Mitochondria consist of hundreds of proteins, most of which are long-lived and inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions is poorly understood. Here we show that mitochondria form spatially defin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-26 | PXD045290 | Pride
Yeast mitochondria aggregates 
ProteomicsDistinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress - Data Set3: VAR1 AP-MS
Mitochondria consist of hundreds of proteins, most of which are long-lived and inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions is poorly understood. Here we show that mitochondria form spatially defin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-26 | PXD045288 | Pride
Yeast mitochondria aggregates 
ProteomicsOla1p trafficking indicates an interaction network between mitochondria, Lipid droplets and stress granules in times of stress
Protein aggregates arise naturally under normal physiological conditions, but their formation is accelerated by age or stress-induced protein misfolding. One of the proteins that accumulate upon stress in yeast cells is Ola1p, know as the “super aggregator” Using a proximity labelling approach based...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-01-26 | PXD045513 | Pride
Protein detoxification  protein aggregation  protein shuttling  stress response: lipid droplets  mitochondria  proximity labelling  turboid 
ProteomicsDistinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress - Data Set2: PIM1 AP-MS
Mitochondria consist of hundreds of proteins, most of which are long-lived and inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions is poorly understood. Here we show that mitochondria form spatially defin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-26 | PXD045286 | Pride
Hsp78 aggregates mitochondria 
ProteomicsDistinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress - Data Set1: HSP78 AP-MS
Mitochondria consist of hundreds of proteins, most of which are long-lived and inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions is poorly understood. Here we show that mitochondria form spatially defin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-26 | PXD045196 | Pride
Hsp78 aggregates mitochondria 
UnknownBiased placement of Mitochondria fission facilitates asymmetric inheritance of protein aggregates during yeast cell division.
Not available
S-EPMC10703421 | biostudies-literature
ProteomicsShotgun measurements of proteome fractionations: mitochondria, aggregates, and soluble fraction of NDUFA11 KO and WT HEK293T cells
Perturbed proteostasis and mitochondrial dysfunction are often associated with age-related diseases such as Alzheimer’s and Parkinson’s diseases. However, the link between them remains incompletely understood. Mitochondrial dysfunction causes proteostasis imbalance, and cells respond to restore prot...
ORGANISM(S): Homo sapiens (Human) 
2023-07-03 | PXD038004 | Pride
Mitochondria Aggregates Tmt Ndufa11 ko 
ProteomicsPrevention of mitochondrial proteotoxicity by formation of a chaperone-dependent protective shell around aggregated polypeptides
The potential proteotoxicity of mitochondrial aggregates in yeast cells is reduced by a sequestration of affected polypeptides into a mitochondrial protein quality control compartment (IMiQ). Based on the expression of an aggregation-prone protein in the mitochondrial matrix, we determined the effec...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-08-21 | PXD059828 | Pride
Mitochondria Hsp70 Chaperone Protein aggregation Proteostasis Yeast 
UnknownFusion, fission, and transport control asymmetric inheritance of mitochondria and protein aggregates.
Not available
S-EPMC5551707 | biostudies-literature
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