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TranscriptomicsPSORS2 is due to mutations in CARD14
Psoriasis is a common, immune-mediated, genetic disorder of the skin associated with arthritis in approximately 30% of cases. Previously, we localized PSORS2 (psoriasis susceptibility locus 2) to chromosome 17q25.3-qter following a genome-wide linkage scan in a family of European origin with multipl...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-36387 | biostudies-arrayexpress
TranscriptomicsMG1655 araC arabinose transcription profiling
AraC is an Escherichia coli transcription factor that regulates genes in response to the presence/absence of arabinose. We used transcription profiling to determine RNA levels in Escherichia coli K-12 strain MG1655 and MG1655 delta araC grown either in the absence or the presence of arabinose. Thus,...
ORGANISM(S): Escherichia coli K-12 
2013-10-19 | E-MTAB-1916 | biostudies-arrayexpress
TranscriptomicsNicotinamide Starvation of Mycobacteria Defective for de novo NAD Biosynthesis
Mycobacteria can synthesize NAD+ using either the de novo biosynthesis pathway or the salvage pathway. The deletion of the three genes involved specifically in the NAD+ de novo biosynthesis pathway in the human pathogen Mycobacterium tuberculosis had no effect on the growth of the strain in vivo. ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-14 | E-GEOD-18909 | biostudies-arrayexpress
Transcriptomics14028s araC RNA-Seq
We used RNA-seq to determine the effects of AraC and arabinose on RNA levels genome-wide in S. enterica. Wild-type or delta araC mutant cells were grown in both the presence and absence of 0.2% L-arabinose. RNA-Seq libraries from two independent biological replicate samples were sequenced for (i) wi...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. 14028s Wu 
2013-10-04 | E-MTAB-1901 | biostudies-arrayexpress
GenomicsSalmonella 14028s AraC ChIP-Seq
We mapped the genome-wide binding of C-terminally FLAG-tagged AraC in S. enterica subsp. enterica serovar Typhimurium strain 14028s using ChIP coupled with deep sequencing (ChIP-seq). We identified five putative target loci for AraC: upstream of araB/araC, araE, araJ, STM14_0178, and within sseD.
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S 
2013-10-09 | E-MTAB-1915 | biostudies-arrayexpress
ProteomicsCD209L/L-SIGN N-Glycosylation and N-Glycosylation Site Occupancy
CD209L is a membrane glycoprotein with known glycan-binding properties and it also contains 2 N-glycosylation sequons at sites N92 and N361. Treatment with PNGase F in the presence of H218O, which removes N-linked glycans and isotopically labels the formerly-glycosylated site, confirmed that both un...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021309 | Pride
Human cd209l Dc-sign N-glycosylation 
ProteomicsMutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability
Ribosomal protein mutations are increasingly associated with cancer risk and thought to perturb ribosome function. At the same time, they reportedly activate p53, a critical anti-cancer barrier. To determine how these mutations overcome this protective block to enable tumorigenesis, we generated an ...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-01 | PXD071901 | Pride
Mouse Ribosomal protein mutations Chronic lymphocytic leukemia 
TranscriptomicsMetabolomic heterogeneity of severe pulmonary arterial hypertension
Although multiple gene and protein expression have been extensively profiled in human pulmonary arterial hypertension (PAH), the mechanism for the development and progression of pulmonary hypertension remains elusive. Analysis of the global metabolomic heterogeneity within the pulmonary vascular sy...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-53408 | biostudies-arrayexpress
ProteomicsSkeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning
Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning
ORGANISM(S): Mus Musculus 
2023-10-24 | PXD046337 |
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