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MetabolomicsExtracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness
The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...
2023-01-17 | MTBLS6661 | MetaboLights
UnknownNOB1 is essential for the survival of RKO colorectal cancer cells.
Not available
S-EPMC4299339 | biostudies-literature
ProteomicsViral control by a unique cytotoxic SARS-CoV-2 spike protein-specific CD4+ T cell population
Little is known of the role of cytotoxic CD4+ T-cells (CTLs) in the control of human viral replication. Here, we investigate CD4+ T-cell responses to three immunodominant SARS-CoV-2 epitopes identified in our study cohort, and evaluate cytotoxic activity and antiviral cytokine production in response...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2025-08-15 | PXD042469 | Pride
Human Epitotpes Sars-cov-2 Cd4+ tcells Lc-ms/ns 
ProteomicsUSP20 promotes T-ALL evolution by deubiquitinating modified HIF1A
Qualitative analysis of proteome is to study the types and quantities of proteome identified by samples under different conditions, and to perform functional analysis of the identified proteins, so as to provide reference information for quantitative and modification analysis of high-throughput prot...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD053080 | Pride
Usp20 Hif1a 
Unknownγδ T cells recruitment and local proliferation in brain parenchyma benefit anti-neuroinflammation after cerebral microbleeds.
Not available
S-EPMC10090560 | biostudies-literature
UnknownCorrelation between miRNA target site polymorphisms in the 3' UTR of AVPR1A and the risk of hypertension in the Chinese Han population.
Not available
S-EPMC6522731 | biostudies-literature
UnknownHigh glucose-upregulated PD-L1 expression through RAS signaling-driven downregulation of PTRH1 leads to suppression of T cell cytotoxic function in tumor environment.
Not available
S-EPMC10337161 | biostudies-literature
UnknownExtracellular acidosis restricts one-carbon metabolism and preserves T cell stemness.
Not available
S-EPMC9970874 | biostudies-literature
UnknownDevelopment and Validation of a Computed Tomography-Based Model for Noninvasive Prediction of the T Stage in Gastric Cancer: Multicenter Retrospective Study.
Not available
S-EPMC11499715 | biostudies-literature
UnknownA comprehensive analysis of the major specificities of anti-human T lymphocyte porcine immunoglobulin (p-ATG).
Not available
S-EPMC11868322 | biostudies-literature
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