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UnknownRevisiting the consequences of deleting the X inactivation center.
Not available
S-EPMC8237661 | biostudies-literature
UnknownCharacterization of Feeding Behaviors, Appetite Regulation and Growth Performance of All-Female (<i>cyp17a1</i>+/-;XX Genotype) Common Carp (<i>Cyprinus carpio</i>).
Not available
S-EPMC11641567 | biostudies-literature
TranscriptomicsGene expression of human isogenic trisomy 21 induced pluripotent stem cells and derived neurons
Down syndrome (trisomy 21) is the most common genetic cause of intellectual disability, but the precise molecular mechanisms underlying impaired cognition remain unclear. Elucidation of these mechanisms has been hindered by the lack of a model system that contains full trisomy of chromosome 21 (Ts21...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-48611 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from wild type or Ercc1 mutant mice
The XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA damage and interstrand crosslinks. Here we have engineered a severe mutation in Ercc1 gene (in which the last 7 amino acids are missing; named as "Ercc1-delta") leading to extreme sensitivity to DNA crosslinks and progeria.To ...
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1503 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver, lung, spleen and kidney from young (13 week) and aged (130 week) wild type mice
We compared the complete mouse liver, spleen, lung and kidney transcriptome of adult 13- and 130-wk old wt C57Bl/6J mice (n=3) to develop gene sets for young adult and aged wt mice, respectively
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1504 | biostudies-arrayexpress
UnknownSirt1 inhibits renal tubular cell epithelial-mesenchymal transition through YY1 deacetylation in diabetic nephropathy.
Not available
S-EPMC8027604 | biostudies-literature
MetabolomicsSerine Metabolism Tunes Immune Responses To Promote Oreochromis niloticus Survival upon Edwardsiella tarda Infection
Overactive immune response is a critical factor triggering host death upon bacterial infection. However, the mechanism behind the regulation of excessive immune responses is still largely unknown, and the corresponding control and preventive measures are also to be explored. In this study, we find t...
2021-08-18 | MTBLS2974 | MetaboLights
ProteomicsUSP20 promotes T-ALL evolution by deubiquitinating modified HIF1A
Qualitative analysis of proteome is to study the types and quantities of proteome identified by samples under different conditions, and to perform functional analysis of the identified proteins, so as to provide reference information for quantitative and modification analysis of high-throughput prot...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD053080 | Pride
Usp20 Hif1a 
UnknownThe CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis.
Not available
S-EPMC8132151 | biostudies-literature
TranscriptomicsSTAG2 is a clinically relevant tumor suppressor in pancreatic ductal adenocarcinoma
STAG2 is targeted by somatic aberrations in a subset (4%) of human PDAs. Transposon mediated disruption of STAG2 in a KRASG12D genetically engineered mouse model promotes the development of PDA and its progression to metastatic disease. There was a statistically significant loss of STAG2 protein exp...
ORGANISM(S): Homo sapiens 
2014-01-24 | E-GEOD-54328 | biostudies-arrayexpress
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