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ProteomicsEpisodic Transport of Protein Aggregates Achieves a Positive Size Selectivity in Aggresome Formation
To generate this dataset, Dynabeads Protein G beads (Thermo Fisher, #10004D) were used to immunoprecipitate different forms of purified AgDD proteins through an HA-tag on the AgDD after incubating AgDD proteins in the Xenopus egg extract. AgDD samples used in the study include AgDD aggregates formed...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-07-16 | PXD054545 | Pride
Xenopus Ip 
ProteomicsEpisodic Transport of Protein Aggregates Achieves a Positive Size Selectivity in Aggresome Formation
To generate this dataset, different proteins (human HDAC6, CCT8, 26S proteasome, Hsc70, Hsp90, p62, and Xenopus HOOK2 were immunoprecipitated from the Hela S3 cell extract or Xenopus egg extract by the Dynabeads Protein G beads (Thermo Fisher, #10004D) coated with corresponding primary antibodies as...
ORGANISM(S): Homo sapiens (Human) 
2025-07-16 | PXD054601 | Pride
Lc-ms Ip 
UnknownSupporting Occupational Justice for Transgender and Gender-Nonconforming People Through Narrative-Informed Theater: A Mixed-Methods Feasibility Study.
Not available
S-EPMC8369667 | biostudies-literature
MetabolomicsImpact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository

INTRODUCTION: Acute lymphoblastic leukemia (ALL) is among the most common cancers in children. With improvements in combination chemotherapy regimens, the overall survival has increased to over 90%. However, the current challenge is to mitigate adverse events resulting from the c...

2021-08-12 | MTBLS2394 | MetaboLights
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
TranscriptomicsInterspecific Introgressive Origin of Genomic Diversity in the House Mouse
We report on a genome-wide scan for introgression in the house mouse (Mus musculus domesticus) involving the Algerian mouse (Mus spretus), using 20 samples from the ranges of sympatry and allopatry. Our analysis reveals significant variability in introgression signatures along the genomes, as well a...
ORGANISM(S): Mus musculus domesticus 
2014-11-01 | E-GEOD-62906 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of Klf2 wild-type and Klf2-Null mESCs cultured under 2i
The self-renewing pluripotent state was first captured in mouse embryonic stem cells (mESCs) over two decades ago. The standard condition requires the presence of serum and LIF, which provide growth promoting signals for cell expansion. However, there are pro-differentiation signals which destabiliz...
ORGANISM(S): Mus musculus 
2014-06-04 | E-MTAB-2366 | biostudies-arrayexpress
GenomicsChIP-seq of Klf2 in mouse embryonic stem cells (Serum/LIF and 2i)
The self-renewing pluripotent state was first captured in mouse embryonic stem cells (mESCs) over two decades ago. The standard condition requires the presence of serum and LIF, which provide growth promoting signals for cell expansion. However, there are pro-differentiation signals which destabiliz...
ORGANISM(S): Mus musculus 
2014-06-04 | E-MTAB-2365 | biostudies-arrayexpress
TranscriptomicsSIRT1 but not its increased expression is essential for lifespan extension in caloric restricted mice.
The SIRT1 deacetylase is one of the best-studied potential mediators of some of the anti-aging effects of calorie restriction (CR); but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespa...
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-46895 | biostudies-arrayexpress
GenomicsA Genome-Wide Association Study of Lung Cancer Risk

Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types genotyping 515,922 single n...

phs000336.v1.p1 | EGA
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