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ProteomicsRadioproteomics stratifies molecular response to antifibrotic treatment in pulmonary fibrosis
Antifibrotic therapy with nintedanib is the clinical mainstay in the treatment of progressive fibrosing interstitial lung disease (ILD). High-dimensional medical image analysis, known as radiomics, provides quantitative insights into organ-scale pathophysiology, generating digital disease fingerprin...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD052594 | Pride
Interstitial lung disease Radiomics Proteomics Multiomics Imaging Lung fibrosis Nintedanib 
UnknownSafety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma.
Not available
S-EPMC3837092 | biostudies-literature
TranscriptomicsRNA-sequencing of transgenic Arabidopsis seedlings constitutively expressing a Colletotrichum higginsianum effector
The fungal pathogen Colletotrichum higginsianum secretes effector proteins during infection of Arabidopsis. To explore the host processes perturbed by the effector candidate ChEC108 in host plants, transgenic Arabidopsis lines were generated to express AtUBQ10pro:ChEC108-eGFP or AtUBQ10pro:ChEC108^D...
ORGANISM(S): Arabidopsis thaliana 
2026-05-21 | E-MTAB-16996 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human head and neck squamous cell carcinomas that are positive or negative for Human Papilloma Virus
Introduction: Human Papilloma Virus (HPV) is associated with a subset of head and neck squamous cell carcinoma (HNSCC), between 15% and 35% of HNSCC harboring HPV, almost exclusively of subtype 16. Demographic and exposure differences between HPV-positive (+) and negative (-) HNSCCs suggest that HPV...
ORGANISM(S): Homo sapiens 
2007-09-20 | E-GEOD-3292 | biostudies-arrayexpress
ProteomicsComparative phyloproteomics identifies conserved plasmodesmal proteins
Plasmodesmata are cytosolic bridges, lined by the plasma membrane and traversed by endoplasmic reticulum, connecting cells and tissues, and critical for many aspects of plant biology. While plasmodesmata are notoriously difficult to extract, tissue fractionation and proteomic analyses can yield valu...
ORGANISM(S): Physcomitrella patens subsp. patens (Moss) Arabidopsis thaliana (Mouse-ear cress) 
2023-01-13 | PXD038964 | Pride
Arabidopsis Plasmodesmata Phyloproteomics Physcomitrium 
TranscriptomicsMesenchymal Nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation
We generated Nfibf/f mice and then cross with Dermo1-Cre mice to obtain Nfibf/f, Dermo1-Cre mice. In these Nfibf/f, Dermo1-Cre mice, there are defects in sacculation and epithelial cell differentiation. We performed micoarray analysis to find the genes which are possibley regulated by NFI-B and rela...
ORGANISM(S): Mus musculus 
2011-09-28 | E-GEOD-24465 | biostudies-arrayexpress
Genomics200PT.bam - samples
200PT : WG Aligned Sequence (bam)/ Aligned WG sequence data in this dataset are from CPCGene Tumour/Normal Pairs used in the 200PT Study
EGAD00001004061 | EGA
TranscriptomicsSKBR3 cells treated with epirubicin or hypoxia
Intratumoral heterogeneity may generate a diversity of resistance mechanisms that could cause different therapeutic responses in different cell populations. Gene expression profiles were generated for breast cancer cells that had survived two different treatment and were also sorted by the cancer st...
ORGANISM(S): Homo sapiens 
2015-09-09 | E-GEOD-72362 | biostudies-arrayexpress
TranscriptomicsSorted tumor RNA-seq of syngeneic murine mutant IDH1 ICC tumor model treated with IDH1 inhibitor against vehicle
IDH1 is the most commonly mutated metabolic gene across human cancers, with the highest mutational frequency observed in AML, glioma, chondrosarcoma, and intrahepatic cholangiocarcinoma. Mutations of the hot spot R132 codon alter the activity of the IDH1 enzyme, resulting in the NADPH-dependent conv...
ORGANISM(S): Mus musculus 
2021-11-23 | E-MTAB-11112 | biostudies-arrayexpress
GenomicsCancer Genetic Markers of Susceptibility (CGEMS) Breast Cancer Genome-Wide Association Study (GWAS) - Primary Scan (Stage 1) - Nurses' Health Study

The Cancer Genetic Markers of Susceptibility (CGEMS) breast cancer genome-wide association study (GWAS) included genotyping 528,173 SNPs (Illumina HumanHap550) in 1,145 postmenopausal women of European ancestry with invasive breast cancer and 1,142 controls from the Nurses' Health Study (...

phs000147.v1.p1 | EGA
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