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MetabolomicsMetabolome and proteome changes in skeletal muscle and blood of pre-weaning calves fed leucine and threonine supplemented diets

In pre-weaning calves, both leucine and threonine play important roles in growth and muscle metabolism. In this study, metabolomics, proteomics and clinical chemistry were used to assess the effects of leucine and threonine supplementation added to milk replacer on 14 newborn Holstein male calves...

2020-02-20 | MTBLS1045 | MetaboLights
Proteomicsglobal phosphoproteomics during human coronavirus infections
For phosphoproteomics analysis, cells were harvested at 24 hours post infections. All samples were analyzed using mass spectrometry with a data-independent analysis (DIA) approach to measure changes in both protein abundancelevel upon infections.
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD057224 | Pride
Phosphoproteomics Human coronavirus 
Proteomicsglobal proteomics profiling of Huh7 cells infected with human coronaviruses (SARS-CoV-2, HCoV-229E, and HCoV-OC43)
To explore host factors and pathways modulated by coronavirus infections, we performed global quantitative proteomics profiling. Huh7 cells were infected with SARS-CoV-2 (MOI=1.0), HCoV-229E (MOI=0.1), or HCoV-OC43 (MOI=1.0) for 24 hours, compared with MOCK infection. Protein samples were digested a...
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD057194 | Pride
ProteomicsIdentification of MELK-interacting proteins in HEK293T cells using IP-MS
To investigate the mechanism by which Maternal Embryonic Leucine Zipper Kinase (MELK) regulates the actin cytoskeleton and affects coronavirus infections, we performed an Immunoprecipitation-Mass Spectrometry (IP-MS) assay. The goal was to identify specific actin-binding proteins that interact with ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD057095 | Pride
ProteomicsIdentification of MELK-mediated Cofilin-1 T70 phosphorylation by IP-LC-MS/MS analysis
To investigate whether MELK phosphorylates Cofilin-1 at residue Threonine 70 (T70), we performed a phosphoproteomic validation using immunoprecipitation coupled with mass spectrometry (IP-LC-MS/MS). HEK293T cells were divided into three experimental groups: (1) MOCK control (Empty Vector), (2) MELK ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD074164 | Pride
Cofilin-1 Melk Immunoprecipitation Affinity purification-ms Otssp167 Hek293t T70 phosphorylation Lc-ms/ms 
MetabolomicsSkeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calves
The effects of different amino acid (AA) supplementations of milk protein-based milk replacers in pre-ruminant calves from 3 days to 7 weeks of age were studied. Animals were divided into 4 groups: Ctrl) Control group fed with milk protein-based milk replacer without supplementation; GP) supplementa...
2018-10-08 | MTBLS720 | MetaboLights
UnknownSkeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calves.
Not available
S-EPMC6138728 | biostudies-literature
UnknownConsensus clustering and development of a risk signature based on trajectory differential genes of cancer-associated fibroblast subpopulations in colorectal cancer.
Not available
S-EPMC11315798 | biostudies-literature
UnknownTYRO3 promotes tumorigenesis and drug resistance in colorectal cancer by enhancing the epithelial-mesenchymal transition process.
Not available
S-EPMC10188355 | biostudies-literature
UnknownDICAR/DICAR-JP exerts therapeutic effects in brain stroke via the miR-361-5p/PRMT1 pathway.
Not available
S-EPMC12722810 | biostudies-literature
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