This study aims to systematically investigate the molecular mechanisms underlying autism spectrum disorder (ASD) by analyzing the proteome and phosphoproteome of a Sh3rf3-deficient mouse model. SH3RF3 (SH3 domain-containing RING finger protein 3) is implicated in synaptic regulation pathways, yet it...
Sh3rf3 is an ASD-associated gene,Sh3rf3 deficiency reduces excitatory synaptic strength in prefrontal cortex and decreases the readily releasable vesicle pool and attenuated vesicle replenishment.To delve into the underlying mechanisms for impaired excitatory transmission, we performed immunoprecipi...
Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites i...
The 4D label free proteomics of membrane vedsicles (MVs) of Staphylococcus aureus RN4220 and the mutants RN4220-ΔHld, which the 20th base “C” in the hld gene was changed to “G” to achieve a stop codon TGA and result in a truncated translation of Hld, and RN4220-ΔagrA, which agrA gene was deleted.
Immunoprecipitation coupled with mass spectrometry (IP/MS) was performed in HaCaT cells using an anti-B7-H3 antibody to identify B7-H3-interacting proteins. Raw mass spectrometry data are provided.
