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ProteomicsRedox regulation of cytosolic translation in rice during fungal infection identified by quantitative proteomics
Pathogen attack can increase plant levels of reactive oxygen species (ROS), which then act as signaling molecules activating plant defense. Elucidating these processes is crucial to understanding the redox signaling pathways in plant defense responses. By an iodo TMT–based quantitative proteomic app...
ORGANISM(S): Oryza sativa (Rice) 
2023-06-06 | PXD034430 | Pride
Ros  protein oxidation  translation  infection  immunity  rice 
ProteomicsRegulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα
Progenitor cells at the basal layer of skin epidermis play an essential role in maintaining tissue homeostasis and enhancing wound repair in skin. The proliferation, differentiation, and cell death of epidermal progenitor cells have to be delicately regulated, as deregulation of this process can lea...
ORGANISM(S): Homo sapiens (Human) 
2020-05-13 | PXD015673 | Pride
Deubiquitination Kdf1 Silac Skin Ikkα Epidermal differentiation Qe-ms 
ProteomicsVIPAS39 confers ferroptosis resistance in ovarian cancer through exporting ACSL4
Ovarian cancer (OC), particularly its epithelial subtype (EOC), is the most lethal gynecological malignancy worldwide, with the majority of patients diagnosed at an advanced stage and a five-year survival rate below 30%. The standard treatment, primarily consisting of cytoreductive surgery and plati...
ORGANISM(S): Homo Sapiens 
2024-08-30 | PXD055446 |
ProteomicsIntegrative analysis of transcriptome and proteome provides insights into adaptation to cadmium stress in Sedum plumbizincicola
Sedum plumbizincicola, a cadmium (Cd) hyperaccumulating herbaceous plant, can accumulate large amounts of Cd in the above-ground tissues without being poisoned. However, the molecular mechanisms regulating the processes are not fully understood. In this study, Transcriptional and proteomic analyses ...
ORGANISM(S): Sedum Plumbizincicola 
2021-09-21 | PXD028688 |
ProteomicsThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5’-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK. ...
ORGANISM(S): Oryctolagus Cuniculus 
2022-08-10 | PXD035968 |
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