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MetabolomicsMetabonomic analysis of human and 12 kinds of livestock mature milk

Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites i...

2023-08-21 | MTBLS6777 | MetaboLights
ProteomicsIdentification of Sh3rf3-interacting proteins in mouse prefrontal cortex by immunoprecipitation mass spectrometry
Sh3rf3 is an ASD-associated gene,Sh3rf3 deficiency reduces excitatory synaptic strength in prefrontal cortex and decreases the readily releasable vesicle pool and attenuated vesicle replenishment.To delve into the underlying mechanisms for impaired excitatory transmission, we performed immunoprecipi...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD061685 | Pride
Prefrontal cortex Mouse Ip-ms Sh3rf3 
ProteomicsSolvent-Induced partial Cellular Fixation Approach enables systematic identification of drug targets and temporal progression of downstream biochemical pathways in living cells
In this study, we introduce a novel approach, the Solvent-Induced Partial Cellular Fixation Approach (SICFA), to monitor drug targets and the temporal progression of downstream biochemical pathways in living cells. We observed that proteins in living cells undergo unfolding and aggregation when expo...
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD057157 | Pride
Proteomics  protein stability  drug target identification  drug binding potency  downstream effector proteins  living cells analysis 
ProteomicsQuantitative proteomic and phosphoproteomic profiling of Sh3rf3-deficient ASD mouse model via 6Plex-TMT and phosphoproteomic
This study aims to systematically investigate the molecular mechanisms underlying autism spectrum disorder (ASD) by analyzing the proteome and phosphoproteome of a Sh3rf3-deficient mouse model. SH3RF3 (SH3 domain-containing RING finger protein 3) is implicated in synaptic regulation pathways, yet it...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD061722 | Pride
Prefrontal cortex Mouse Ms Sh3rf3 
ProteomicsProteome-wide identification of S-sulfenylated cysteines reveals metabolic adaptation to freezing stress after cold acclimation in Brassica napus
We performed an iodoTMT-based proteomic analysis to identify the redox sensitive proteins in vivo under freezing stress after cold acclimation in Brassica napus. Totally, we obtained 1,372 sulfenylated sites in 714 proteins. Here we will provide the MS data of iodoTMT labeled peptides under both c...
ORGANISM(S): Brassica Napus 
2022-06-16 | PXD034549 |
ProteomicsDifferential Mitochondrial proteomics analysis of A549 cells infected with H5 and H9 subtypes of avian influenza viruses
The temporal response of primary human alveolar adenocarcinoma epithelial cells (A549) infected with H5N1 influenza virus and H9N2 influenza A viruswere evaluated using the proteomics approaches (2D-DIGE combined with MALDI-TOF-MS/MS) at 24 hours post of the infection .
ORGANISM(S): Homo Sapiens 
2020-03-06 | PXD017921 |
Proteomics4D label free proteomics of membrane vesicles of RN4220 and the mutants RN4220-ΔHld and RN4220-ΔagrA
The 4D label free proteomics of membrane vedsicles (MVs) of Staphylococcus aureus RN4220 and the mutants RN4220-ΔHld, which the 20th base “C” in the hld gene was changed to “G” to achieve a stop codon TGA and result in a truncated translation of Hld, and RN4220-ΔagrA, which agrA gene was deleted.
ORGANISM(S): Staphylococcus Aureus 
2023-01-29 | PXD039734 |
ProteomicsUrinary proteome and metabolome uncover tumor microenvironment and cellular metabolism changes of renal clear cell carcinoma
We applied LC-MS to profile the urine proteome and metabolome of 314 ccRCC, 341 healthy control and 49 kidney benign disease enrolled from three cohorts to a great depth. Functionally, we revealed significant changes of extracellular matrix (ECM) organization, complement and coagulation cascades, am...
ORGANISM(S): Homo Sapiens 
2025-05-22 | PXD064183 |
ProteomicsAptamer-Mediated Proximity Labeling (ApMPL) for Spatially Resolved Deciphering Cell Membrane Protein Interactome
Cell membrane protein-protein interactions (PPIs) play pivotal roles in maintaining cellular homeostasis and physiological balance. Deciphering these interactions is crucial for understanding disease mechanisms and identifying therapeutic targets. While proximity labeling technologies have revolutio...
ORGANISM(S): Homo Sapiens 
2026-02-27 | PXD074981 |
ProteomicsProteomic stratification of prognosis and treatment options for small cell lung cancer
We analyzed surgically resected formalin-fixed, paraffin-embedded (FFPE) SCLC samples by proteomic profiling and stratified SCLC into three subtypes (S-I, S-II, and S-III) with distinct clinical outcomes and chemotherapy responses.
ORGANISM(S): Homo Sapiens 
2025-05-27 | PXD064316 |
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