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GenomicsInitiation of a ZAKa-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L
Initiation of a ZAKa-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L
PRJNA1066218 | ENA
ProteomicsRibosome impairment regulates intestinal stem cell identity via ZAKa activation.
The small intestine is a rapidly proliferating organ that is maintained by a small population of Lgr5-expressing intestinal stem cells (ISCs). However, several Lgr5-negative ISC populations have been identified, and this remarkable plasticity allows the intestine to rapidly respond to both the local...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-13 | PXD033122 | Pride
Zaka Proteomics Lc-msms Intestinal stem cells 
OtherStalled ribosomes are signals for metabolic regulation by the ribotoxic stress response
Impairment of translation can lead to stalling and collision of ribosomes which constitute an activation platform for several ribosomal stress-surveillance pathways. Among these is the Ribotoxic Stress Response (RSR), where ribosomal sensing by the MAP3K ZAKa leads to activation of p38 and JNK kinas...
ORGANISM(S): Mus musculus 
2022-11-16 | GSE205191 | GEO
TranscriptomicsInitiation of a ZAKa-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L
RNase L is a regulated endoribonuclease in higher vertebrates that functions in antiviral innate immunity. Interferons induce OAS enzymes that sense double-stranded RNA of viral origin leading to synthesis of 2’,5’-oligoadenylate (2-5A) activators of RNase L. However, it is unknown precisely how RNa...
ORGANISM(S): Mus musculus 
2024-03-01 | GSE253530 | GEO
UnknownZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome.
Not available
S-EPMC10565642 | biostudies-literature
TranscriptomicsZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains
Impairment of ribosome function activates the MAPKKK ZAK, leading to activation of mitogen-activated protein (MAP) kinases p38 and JNK and inflammatory signaling. The mechanistic basis for activation of this ribotoxic stress response (RSR) re-mains completely obscure. We show that the long isoform o...
ORGANISM(S): Homo sapiens 
2020-04-15 | GSE131201 | GEO
OtherZAK-alpha is a sensor of mRNA stasis at the ribosomal exit channe
Despite growing interest in the ribotoxic stress response (RSR), it remains unknown how the upstream p38 and JNK-activating MAP3 kinase ZAK-alpha senses translational impairment. Combining Alphafold3 prediction and RNA crosslinking and immunoprecipitation (CLIP), we uncover that ZAK-alpha dynamicall...
ORGANISM(S): Homo sapiens 
2026-07-01 | GSE314163 | GEO
UnknownPsychological predictors of protective behaviours during the Covid-19 pandemic: Theory of planned behaviour and risk perception.
Not available
S-EPMC8093925 | biostudies-literature
UnknownModel-Based Integration Analysis Revealed Presence of Novel Prognostic miRNA Targets and Important Cancer Driver Genes in Triple-Negative Breast Cancers.
Not available
S-EPMC7139587 | biostudies-literature
UnknownEffects of silver-decorated PLGA nanoparticles on Staphylococcus epidermidis biofilms and evaluation of the detoxification limit of bacteria against these nanoparticles.
Not available
S-EPMC11404029 | biostudies-literature
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