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ProteomicsIdentification of substrates of ZDHHC20 in a mouse pancreatic carcinoma cell line
An shRNA screen to search for the mediators of pancreatic cancer metastasis identified palmitoyl transferase ZDHHC20 as a protein that mediates this process by promoting the outgrowth of metastatic cells in vivo. We sought to identify the substrates of ZDHHC20 by using an engineered mutant of ZDHHC2...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-09 | PXD036914 | Pride
Zdhhc20 Palmitoylation Pdac Pancreatic cancer 
ProteomicsIdentification of Zdhhc20 knock-down cell palmitome
An shRNA screen to search for the mediators of pancreatic cancer metastasis identified palmitoyl transferase ZDHHC20 as a protein that mediates this process by promoting the outgrowth of metastatic cells in vivo. We sought to identify the changes in the palmitome of the cells expessing scrambled shR...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-09 | PXD038048 | Pride
Zdhhc20 Pdac Pancreatic cancer 
GenomicsIdentification of the Zdhhc20 KO transcriptome
Identification of the Zdhhc20 KO transcriptome
PRJNA911909 | ENA
GenomicsZDHHC20-Mediated S-Palmitoylation of YTHDF3 Stabilizes MYC mRNA to Promote Pancreatic Cancer Progression
ZDHHC20-Mediated S-Palmitoylation of YTHDF3 Stabilizes MYC mRNA to Promote Pancreatic Cancer Progression
PRJNA986177 | ENA
TranscriptomicsIdentification of the Zdhhc20 KO transcriptome
Metastasis is one of the defining features of pancreatic ductal adenocarcinoma (PDAC) that contributes to poor prognosis. In this study, the palmitoyl transferase ZDHHC20 was identified in an in vivo shRNA screen as critical for metastatic outgrowth, with no effect on proliferation and migration in ...
ORGANISM(S): Mus musculus 
2023-02-09 | GSE220914 | GEO
ProteomicsIdentification of cell surface proteins in Zdhhc20 KO cells
An shRNA screen to search for the mediators of pancreatic cancer metastasis identified palmitoyl transferase ZDHHC20 as a protein that mediates this process by promoting the outgrowth of metastatic cells in vivo, We generated a KO of Zdhhc20 using Cas9/CRISPR and sought to determine the changes in t...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-09 | PXD038384 | Pride
Cell surface Zdhhc20 Pdac Pancreatic cancer 
TranscriptomicsZDHHC20-Mediated S-Palmitoylation of YTHDF3 Stabilizes MYC mRNA to Promote Pancreatic Cancer Progression
Post-translational modifications of malignant transformation and tumor maintenance in pancreatic ductal adenocarcinoma (PDAC) in the context of KRAS signaling remains largely unexplored. Here, we used the KPC mouse model to examine the effect of palmitoylation on pancreatic cancer progression. ZDHHC...
ORGANISM(S): Homo sapiens 
2024-04-22 | GSE235516 | GEO
UnknownZDHHC20 mediated S-palmitoylation of fatty acid synthase (FASN) promotes hepatocarcinogenesis.
Not available
S-EPMC11657817 | biostudies-literature
UnknownZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression.
Not available
S-EPMC11143236 | biostudies-literature
UnknownCharting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20.
Not available
S-EPMC9575173 | biostudies-literature
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