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MetabolomicsFasting wildtype, tfeb -/- knockout, and lmna -/- knockout metabolite profiling of adult zebrafish
Not available
ORGANISM(S): Danio rerio 
ST000584 | MetabolomicsWorkbench
MetabolomicsA robust method for performing 1H-NMR lipidomics in embryonic zebrafish
The embryonic zebrafish is an ideal system for lipid analyses with relevance to many areas of bioscience research, including biomarkers and therapeutics. Research in this area has been hampered by difficulties in extracting, identifying and quantifying lipids. We employed 1H-NMR at 700MHz to profile...
2024-07-02 | MTBLS2396 | MetaboLights
TranscriptomicsTranscriptomic analyses of Myc-induced zebrafish liver cancer
To study the characteristics and mechanisms of Myc-induced zebrafish liver tumor, next-generation sequencing-based SAGE analyses were used to examine the transcriptomes of tumor and control samples. The results indicated that ribosome proteins were overwhelmingly up-regulated in the Myc-induced live...
ORGANISM(S): Danio rerio 
2013-04-02 | E-GEOD-40745 | biostudies-arrayexpress
ProteomicsQuantitative proteomics analysis of WT and tfeb-tfe3s triple knock-out zebrafish adult liver and embryos at 5 days post fertilization
The transcription factors tfeb and tfe3 belong to the MiT/TFE gene family and are known as master regulators of lysosomal function and autophagy. In normal conditions, they are sequestered in the cytosol of the cells and their nuclear translocation is finely regulated in response to a huge array of ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-05-20 | PXD056508 | Pride
Zebrafish adult liver Tmt-multiplex labeling Zebrafish embryos Lc-ms/ms 
ProteomicsDIA-based quantitative proteomic analysis of adult sec31a-nju221 zebrafish liver
We found that adult zebrafish bearing a homozygous hypomorphic mutation in the sec31a gene (sec31anju221) exhibited overt glycogenic hepatopathy. As an efforts to investigate how hepatic metabolic maladaptation happened in sec31anju221 fish, livers were dissected from the adult zebrafish and DIA-MS ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-08-28 | PXD048925 | Pride
Dia Sec31a Liver Zebrafish 
ProteomicsQuantification of brain, muscle, and liver using large SWATH-spectral library
Sequential window acquisition of all theoretical mass spectra (SWATH-MS) requires a spectral library to extract quantitative measurements from the mass spectrometry data acquired in data-independent acquisition mode (DIA). Large combined spectral libraries containing SWATH assays have been generated...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-12-18 | PXD010869 | Pride
Brain Liver Zebrafish Muscle 
ProteomicsHepatic processing of Z variant α-1-antitrypsin alters ERAD capacity to regulate cholesterol biosynthesis in a zebrafish model
Homozygosity for the Z allele of α1-antitrypsin (ZAAT) predisposes affected individuals to developing liver disease as the serpin misfolds and forms insoluble polymers that accumulate in the endoplasmic reticulum (ER) of hepatocytes, resulting in gain-of-function hepatotoxicity. This prevents secret...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2023-03-10 | PXD036830 | Pride
Alpha-1-antitrypsin  serpina1  zebrafish  liver  erad 
ProteomicsAsialoglycoprotein receptor subunit ASGR1a deficiency leads to cholesterol malabsorption in zebrafish on a high cholesterol diet
One of the major pathways to clear glycoproteins from circulation is via the liver-specific asialoglycoprotein receptor (ASGPR). Recently, loss of asialoglycoprotein receptor 1 (ASGR1), the major subunit of ASGPR in humans, was found to correlate with lower levels of plasma apolipoprotein B-containi...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2026-09-07 | PXD078307 | Pride
Asgr1 Steatosis Cholesterol Liver Zebrafish 
TranscriptomicsChIP-chip by array of zebra fish hepatocellular carcinoma and normal liver to detect differences in CG island methylation
The aim of the experiment was to detect differences in CG island methylation between hepatocellular carcinoma and normal liver in zebrafish. Zebrafish were treated with DMBA, producing hepatocellular carcinoma, genomic DNA was prepared from these and control zebrafish livers. Methylated DNA was immu...
ORGANISM(S): Danio rerio 
2011-01-01 | E-MTAB-209 | biostudies-arrayexpress
TranscriptomicsMycobacterium marinum chronic infection of adult zebrafish
Novel high-throughput deep sequencing technology has dramatically changed the way that the functional complexity of transcriptomes can be studied. Here we report on the first use of this technology to gain insight into the wide range of transcriptional alterations that are associated with an infecti...
ORGANISM(S): Danio rerio 
2009-06-29 | E-GEOD-14782 | biostudies-arrayexpress
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