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ProteomicsHuman melanoma cell lines secretome analysis
The imbalance of cellular homeostasis during oncogenesis together with the high heterogeneity of tumor-associated stromal cells have a marked effect on the repertoire of the proteins secreted by malignant cells (the secretome). Hence, the study of tumoral secretomes provides insights for understandi...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD007265 | Pride
Cancer Proteomics Melanoma Secretome 
ProteomicsProteomic profiling of the proteolytic events in the secretome of the transformed phenotype of melanocyte-derived cells using Terminal Amine Isotopic Labeling of Substrates
The comprehensive profiling of the repertoire of secreted proteins from cancer cells and/or tissue samples provides information on the signaling events that take place during oncogenesis as well as on the cross-talk between normal and tumoral cells. Moreover, the analysis of post translational modif...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-02 | PXD010169 | Pride
Cancer Proteomics Keywords: secretome Tails Melanoma N-terminomics 
ProteomicsEmerging connectivity patterns of protein-protein interaction networks in melanoma secretome: insights into the cancer interactome
Cellular communication strongly relies on the secretion of soluble mediators that, in general, interact with cell surface receptors and enable biological responses in a proper timescale for signaling processes to occur. Therefore, the study of secreted proteins (the secretome) from normal cells and ...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-07 | PXD015114 | Pride
Tgf beta. Melanoma Complex network analysis Secretome Interactome 
ProteomicsA snapshot of Bothrops jararaca snake venom gland subcellular proteome
The synthesis of snake venom proteins is subjected to finely regulated processes in the specialized secretory epithelium within the venom gland. Such processes occur within a defined time frame in the cell and at specific cellular locations. Thus, the determination of subcellular proteomes allows th...
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2023-09-30 | PXD040239 | Pride
Bothrops jararaca Snake venom Snake venom gland Proteome Subcellular fractionation 
ProteomicsQualitative and quantitative analysis of Bothrops jararaca venom gland proteome
While cellular transcripts encode rich information that provide key features to understand the molecular basis of snake venom variation, their presence/ abundance does not necessary imply/correlate in the translation of a functional (protein) product. In this study we carried out an analysis of the ...
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2016-09-28 | PXD004186 | Pride
Venom gland proteome Snake venom proteome Bothrops jararaca Venom variability 
ProteomicsSalivary Proteomics Reveals Oxidative and Inflammatory Markers in E-Cigarette Users
Electronic cigarettes, also known as ecig-s, have been widely used in recent years, especially among younger populations. Cytotoxic and carcinogenic substances can be present in their composition, but little is known about the risks associated with their use. The purpose of this study was to evaluat...
ORGANISM(S): Homo sapiens (Human) 
2026-03-10 | PXD066133 | Pride
Proteome  saliva  electronic cigarette uses  electronic nicotine delivery systems  glutathione transferase. 
ProteomicsCombining information on degradomics and gene expression data in prospecting metastatic melanoma proteolytic signatures
Melanoma is an aggressive skin cancer with a high metastatic potential, influenced by both genetic and environmental factors. Proteases play a key role in shaping the tumor microenvironment and enabling transformed cells to actively colonize distant sites (metastasis). We performed proteomic mapping...
ORGANISM(S): Homo sapiens (Human) 
2026-01-02 | PXD062309 | Pride
Proteolytic signaling Melanoma Proteolysis Formalin-fixed paraffin-embedded. 
ProteomicsA systemic view of active site specificity profiling of the snake venom metalloprotease HF3 using Proteomic Identification of Cleavage Sites and N-terminomics TAILS
Snake venom metalloproteinases play important roles in the pathological effects of Viperidae venoms including severe local tissue damage, hemorrhage and coagulopathy. Hemorrhagic Factor 3 (HF3), a metalloproteinase isolated from Bothrops jararaca venom, induces severe local hemorrhage. Previous prot...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-29 | PXD009201 | Pride
N-terminome Snake venom metalloprotease Snake venom Hf3 Tails Degradomics 
ProteomicsHeterotypic signaling between dermal fibroblasts and melanoma cells induces phenotypic plasticity and proteome rearrangement in malignant cells
The signaling events triggered by soluble mediators released from both transformed and stromal cells shape the phenotype of tumoral cells and have significant implications in cancer development and progression. In this study we performed an in vitro heterotypic signaling assay by evaluating the prot...
ORGANISM(S): Homo sapiens (Human) 
2020-08-31 | PXD020426 | Pride
Cancer-associated fibroblasts Heterotypic signaling Fibroblast Phenotypic plasticity. Melanoma 
ProteomicsSnake venom serine proteinases specificity mapping by proteomic identification of cleavage sites
Serine proteinases have been shown to play the role of toxins in the venoms of many snakes. They act mainly on components of the coagulation cascade, and fibrinolytic and kallikrein-kinin systems to trigger various pathological effects observed in the envenomation. Despite showing high similarity in...
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2014-10-30 | PXD001217 | Pride
Serine proteinase Pproteomic identification of protease cleavage sites Mass spectrometry Snake venom Proteinase 
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