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Dysfunctional proteostasis is increasingly implicated in neurodegenerative diseases which is exemplified by an accumulation of protein aggregates in the brain in e.g. Alzheimer's and Parkinson's disease. In addition, in Alzheimer's disease there is an accumulation of autophagic vesicles within neuri...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD012851 | Pride
Biomarkers of neurodegenerative disorders are needed to assist in diagnosis, to monitor disease progression and therapeutic interventions, and to provide insight into disease mechanisms. One route to identify such biomarkers is by proteomic and peptidomic analysis of cerebrospinal fluid (CSF). In t...
ORGANISM(S): Homo sapiens (Human) 
2017-01-17 | PXD004863 | Pride
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