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ProteomicsIntegrative proteome and acetylome analyses of murine responses to Cryptococcus neoformans infection
Cryptococcus neoformans, an environmental opportunistic human fungal pathogen, is a causative agent for acute pulmonary infection and meningoencephalitis. Understanding the host’s response to C. neoformans infection is critical for developing effective treatment. Even though some have elucidated the...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-21 | PXD016614 | Pride
Lysine acetylome Mouse lung Cryptococcus neoformans infection Mouse brain 
UnknownLong-term cardiovascular risk and mortality associated with uric acid to HDL-C ratio: a 20-year cohort study in adults over 40.
Not available
S-EPMC12022283 | biostudies-literature
ProteomicsQuantitative analysis of the global proteome of heart tissue in septic shock
Nowadays, sepsis and septic shock have become major public health problems, which are the main cause of death among patients admitted to the intensive care units. Notably, myocardial dysfunction during sepsis, usually called sepsis-induced myocardial depression, is common in septic shock patients wh...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-19 | PXD029649 | Pride
Shock Sepsis Proteome Myocardial depression 
TranscriptomicsExpression data from conditional Klf5 knockout Pten-null mouse prostates
KLF5 is a basic transcription factor that regulates multiple biological processes, but its function in tumorigenesis appears contradictory in the current literature, with some studies showing tumor suppressor activity and others showing tumor promoting activity. In this study, we examined the functi...
ORGANISM(S): Mus musculus 
2014-06-21 | E-GEOD-58719 | biostudies-arrayexpress
MetabolomicsThe gut microbiota-butyrate axis restores cardiomyocyte autophagy to alleviate Doxorubicin-induced cardiotoxicity

Abstract

Background Doxorubicin (DOX), an anthracycline chemotherapeutic agent, is widely used for treating various malignancies. However, its clinical application is limited by dose-dependent cardiotoxicity (DOX-induced cardiotoxicity, DIC). Recent studies have shown that the gut microbiot...

2025-09-16 | MTBLS12997 | MetaboLights
UnknownMicroRNA-590 Inhibits Lipoprotein Lipase Expression and Prevents Atherosclerosis in apoE Knockout Mice.
Not available
S-EPMC4580638 | biostudies-literature
UnknownRole of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease.
Not available
S-EPMC10726594 | biostudies-literature
ProteomicsCheA pupylation sites identified by SPIDER assay
We used CheAs and biotin-CheZ to validate the efficiency of SPIDER capturing protein-protein interaction. Pupylation sites on WT CheAs after SPIDER assay was identified by LC-MS/MS analysis, by searching for an additional mass of ~243 Da, which represents the three C-terminal residues of Pup, i. e.,...
ORGANISM(S): Escherichia Coli 
2021-06-04 | PXD026509 |
ProteomicsPupylation sites on protein Sox2
As a test for the effectiveness of SPIDER with RNA-protein pairs, We used Sox2 and specific biotin-DNA and biotin-RNA to validate the efficiency of SPIDER capturing protein-nucleic acid interaction. Pupylation sites on Sox2 after SPIDER assay was identified by LC-MS/MS analysis, by searching for an ...
ORGANISM(S): Homo Sapiens 
2021-06-04 | PXD026517 |
ProteomicsA proteomic landscape of macrophage in mouse tissues
Macrophages, locating in essentially all tissues, are critical for innate immune responses and involved in the tissue homeostasis. Distinct macrophages populations in different tissues exhibited diverse gene expressions and biological processes. Previous studies have accessed the molecular signature...
ORGANISM(S): Mus Musculus 
PXD021583 |
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