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ProteomicsQuantitative Proteomics Reveals a Role for Epigenetic Reprogramming During Human Monocyte Differentiation
The data submitted is for the proteomics data published in the paper: Quantitative proteomics reveals a role for epigenetic reprogramming during human monocyte differentiation D Nicholas, H Tang, Q Zhang, J Rudra, F Xu, W Langridge, K Zhang Molecular & Cellular Proteomics 14 (1), 15-29.
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD058308 | Pride
Epigenetics Macrophages Monocyte Quantitative proteomics Dendritic cells 
ProteomicsThe impact of Bisphenol A on immunity and asthmatic inheritance revealed from a major proteomics study
Environmental estrogens, such as bisphenol A (BPA) that is normally used in the manufacture of food and beverage containers, pose increasingly worrisome hazards to human and wildlife health. The adverse effects of BPA are multifaceted; while close attention has been paid to their effect on the immun...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-12-16 | PXD014275 | Pride
Bisphenol a Asthma Immune response Proteomics 
ProteomicsMulti-OMICs analysis of metabolites, proteins, and histone modifications during human macrophage polarization reveals novel regulatory pathways
Macrophages are phagocytic cells in the innate immune system that infiltrate into resident tissues and subsequently polarize into at least two classical phenotypes: ‘pro-inflammatory’ M1 and ‘anti-inflammatory’ M2. Aberrant polarization can aggravate the pathophysiology of infectious diseases such a...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD030701 | Pride
Multi-omics. Macrophage 
ProteomicsProteome of Hypoxic Glioblastoma Cells
Tumors are known for hypoxic microenvironment due to decreased hemoglobin oxygen saturation arising from high acidity in tumor tissue, high consumption rates of rapidly proliferating cells, and irregular or even short-time cessation of blood flow in deformed vessels. Consequently, hypoxia promotes t...
ORGANISM(S): Homo sapiens (Human) 
2017-09-12 | PXD005487 | Pride
Glioblastoma Hypoxia 
ProteomicsProteome analysis of hypoxic glioblastoma cells reveals sequential metabolic adaptation of one-carbon metabolic pathways
Rapidly proliferating tumors are exposed to a hypoxic microenvironment due to their density, high metabolic consumption, and interruptions in blood flow due to immature angiogenesis. Cellular responses to hypoxia promote highly malignant and metastatic behavior, as well as a chemotherapy-resistant s...
ORGANISM(S): Homo sapiens (Human) 
2017-09-07 | PXD007280 | Pride
Proteomics One carbon Protein pathways Hypoxia 
ProteomicsMeasurement of deaminated cytosine adducts in DNA using a novel hybrid thymine DNA glycosylase
The hydrolytic deamination of cytosine and 5-methylcytosine drives many of the transition mutations observed in human cancer. The deamination-induced mutagenic intermediates are either uracil or thymine adducts mispaired with guanine. While a substantial array of methods exists to measure other type...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD030459 | Pride
Glycosylase Deamination Dna repair Mass spectrometry Dna damage Cytosine Mutation 
TranscriptomicsChromatin immunoprecipitation of yeast using anti-H3C and anti-K56 antibodies
Chromatin immunoprecipitation DNA by H3 K56 acetylation antibody
ORGANISM(S): Saccharomyces cerevisiae 
2007-09-28 | E-MEXP-1248 | biostudies-arrayexpress
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