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TranscriptomicsTranscription profiling of human intestinal cells (Caco-2) and tissues from all intestinal segments (duodenum, jejunum, ileum, colon)
Affymetrix U95Av2 expression data from human intestinal cells (Caco-2) and tissues from all intestinal segments (duodenum, jejunum, ileum, colon). Entries contain the search terms glycosylase, phosphorylase, cytochrome or nucleoside, which were relevant to our search for enzymes capable of cleaving...
ORGANISM(S): Homo sapiens 
2007-06-21 | E-GEOD-1862 | biostudies-arrayexpress
TranscriptomicsThe RON receptor tyrosine kinase promotes metastasis by triggering epigenetic reprogramming through the thymine glycosylase MBD4 (RNA-Seq)
Metastasis is the major cause of death in cancer patients, yet the genetic/epigenetic programs that drive metastasis are poorly understood. Here, we report a novel epigenetic reprogramming pathway that is required for breast cancer metastasis. Concerted differential DNA methylation is initiated by a...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-52687 | biostudies-arrayexpress
TranscriptomicsLoss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents.
The nematode Caenorhabditis elegans has been used extensively to study responses to DNA damage. In contrast, little is known about DNA repair in this organism. C. elegans is unusual in that it encodes few DNA glycosylases and the uracil-DNA glycosylase (UDG) encoded by the ung-1 gene is the only kno...
ORGANISM(S): Caenorhabditis elegans 
2010-06-08 | E-GEOD-21467 | biostudies-arrayexpress
TranscriptomicsThe RON receptor tyrosine kinase promotes metastasis by triggering epigenetic reprogramming through the thymine glycosylase MBD4 (gene expression array)
Metastasis is the major cause of death in cancer patients, yet the genetic/epigenetic programs that drive metastasis are poorly understood. Here, we report a novel epigenetic reprogramming pathway that is required for breast cancer metastasis. Concerted differential DNA methylation is initiated by a...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-52567 | biostudies-arrayexpress
ProteomicsMeasurement of deaminated cytosine adducts in DNA using a novel hybrid thymine DNA glycosylase
The hydrolytic deamination of cytosine and 5-methylcytosine drives many of the transition mutations observed in human cancer. The deamination-induced mutagenic intermediates are either uracil or thymine adducts mispaired with guanine. While a substantial array of methods exists to measure other type...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD030459 | Pride
Glycosylase Deamination Dna repair Mass spectrometry Dna damage Cytosine Mutation 
GenomicsGenome-wide distribution of 5-formylcytosine in ES cells is associated with transcription and depends on TDG
Methylation of cytosine in DNA (5mC) is an important epigenetic mark that is involved in the regulation of genome function. During early embryonic development in mammals, the DNA methylation landscape is dynamically reprogrammed in part through active demethylation. Recent advances have identified k...
ORGANISM(S): Mus musculus 
2012-08-17 | E-GEOD-40148 | biostudies-arrayexpress
TranscriptomicsUNG shapes the specifity of AID-induced somatic hypermutation in B cells
Secondary diversification of antibodies through somatic hypermutation (SHM) and class switch recombination (CSR) is a critical component of the immune response. Activation-induced deaminase (AID) initiates both processes by deaminating cytosine residues in immunoglobulin genes. The resulting U:G mis...
ORGANISM(S): Mus musculus 
2012-07-04 | E-GEOD-39114 | biostudies-arrayexpress
TranscriptomicsUNG shapes the specifity of AID-induced somatic hypermutation in non B cells
Secondary diversification of antibodies through somatic hypermutation (SHM) and class switch recombination (CSR) is a critical component of the immune response. Activation-induced deaminase (AID) initiates both processes by deaminating cytosine residues in immunoglobulin genes. The resulting U:G mis...
ORGANISM(S): Mus musculus 
2012-07-04 | E-GEOD-39108 | biostudies-arrayexpress
ProteomicsTime-resolved analysis of vUNG phosphorylation
Time-resolved phosphoproteomic analysis of HEp-2 cells infected with wild type HSV-1(F)
ORGANISM(S): Cellular Organisms 
2025-06-03 | PXD055199 | JPOST Repository
ProteomicsMS-based determination of vUNG phosphorylation
Phosphoproteomic analysis of HEp-2 cells infected with wild type HSV-1(F)
ORGANISM(S): Cellular Organisms 
2025-06-03 | PXD043453 | JPOST Repository
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