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MetabolomicsDiscover the Maze-like Pathway for Glabridin Biosynthesis

Glabridin is a bioactive isoflavan predominantly produced in Glycyrrhiza species and is of significant pharmacological and industrial interest. However, its biosynthetic pathway remains incompletely resolved due to the involvement of multiple branching reactions and poorly characterized...

2026-01-16 | MTBLS13519 | MetaboLights
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
ProteomicsProteomics analysis of nuclear envelope, cytoplasmic membrane and nuclear contents fractions isolated from mesenchymal stem cells, adipocytes and myocytes
We used shotgun proteomics to analyze three subcellular fractions isolated from mesenchymal stem cells and from differentiated adipocytes and myocytes: nuclear envelopes (NEs), cytoplasmic membranes and nuclear contents. The proteomics data were analyzed by a NSAF-based scoring system to calculate...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-11-27 | MSV000083166 | MassIVE
ProteomicsGlobal profiling of protein lactylation in Human hippocampi
Lysine lactylation (Kla) is a novel posttranslational modification, playing important roles in numerous biological processes, including transcription, metabolism, tumorigenesis and nervous system diseases. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), researchers have identified l...
ORGANISM(S): Homo Sapiens 
2024-03-08 | PXD050470 |
ProteomicsComparative membrane proteomics reveals diverse cell regulators concentrated at the nuclear envelope
The nuclear envelope (NE) is a subdomain of the ER with a distinctive protein composition that underpins its role in nuclear compartmentalization. To expand an understanding of NE functions, we refined methods to reveal low abundance transmembrane (TM) proteins concentrated at the NE. De facto, th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-25 | MSV000091154 | MassIVE
MetabolomicsCell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells

Multicellular organisms such as plants contain various cell types with specialized functions. Analyzing the characteristics of each cell type reveals specific cell functions and enhances our understanding of organization and function at the organismal level. Guard cells (GCs) are specialized epid...

2024-09-03 | MTBLS3997 | MetaboLights
ProteomicsMouse Cardiac Proteomics and β-hydroxybutyrylation omics Studies
β-Hydroxybutyrylation (kbhb) is a new type of post-translational modification(PTM) of lysine acylation. In recent years, kbhb modification has been shown to be involved in energy metabolism, tumor metabolism, DNA damage repair and other processes. Currently, lysine β-hydroxybutyrylation has not ...
ORGANISM(S): Mus Musculus 
2023-03-14 | PXD034269 |
ProteomicsProteome profiling of normal epithelium, tubular adenoma, tubulovillous adenoma, high-grade neoplasia, cancer tissues in colorectum
Most of the carcinogenesis of colorectal cancer (CRC) follows the normal-adenoma-carcinoma (N-A-C) sequence. We aimed to identify the key proteins in the N-A-C sequence and describe the proteomic pattern of tubular adenoma, tubulovillous adenoma and high-grade neoplasia. This study used high-resolut...
ORGANISM(S): Homo Sapiens 
2021-01-30 | PXD023899 |
ProteomicsCarnosol alleviating C26 induced Cancer Cachexia
Shotgun proteomics using LC-high resolution tandem mass spectrometry was applied to check the protein expression profiles of C2C12 myotubes in control group (treated with solvent control 0.1% DMSO), C26 medium group (treated with conditioned medium of C26 tumor cells for 48 h), CS group (treated wit...
ORGANISM(S): Mus Musculus 
2023-07-02 | PXD043464 |
ProteomicsFunctional identification of protocadherin alpha 9 (PCDHA9) as a candidate causative gene for amyotrophic lateral sclerosis
Mice were sacrificed after anesthesia by isoflurane following neck cutting. The spinal cord L3-L5 was taken and frozen in liquid nitrogen immediately and the ventral horn of the bilateral spinal cord (about 400um thick in gray matter area) was collected at low temperature. The samples were digested ...
ORGANISM(S): Mus Musculus 
2023-06-12 | PXD042929 |
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