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ProteomicsNanoparticle-aided nanoreactor for large-scale proteomics of few mammalian cells
Large-scale bottom-up proteomics of few even single cells is crucial for a better understanding of the roles played by cell-to-cell heterogeneity in disease and development. Novel proteomic methodologies with extremely high sensitivity are required for few even single-cell proteomics. Sample process...
ORGANISM(S): Homo sapiens (Human) 
2022-07-11 | PXD027135 | Pride
Nanoreactor Single-cell proteomics Mass-limited sample Nanoproteomics Bottom-up proteomics Nanoparticle Few-cell proteomics 
ProteomicsA bioenergetic shift is required for spermatogonial differentiation
A bioenergetic balance between glycolysis and mitochondrial respiration is particularly important for stem cell fate specification. It however remains to be determined whether undifferentiated spermatogonia switch their preference of bioenergy production during differentiation. In this study, we fou...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD019136 | Pride
Spermatogonial differentiation Oxphos Glycolysis 
ProteomicsCTCF couples long-range loop extrusion and diffusional mechanism to mediate a diverse Igk repertoire
Dynamic genome folding plays a crucial role in cellular functions, including V(D)J recombination at the immunoglobulin kappa (Igκ) locus for antibody generation. This process involves frequent recombination between Jκ and Vκ gene segments over a 3.2 Mb region in both deletional and inversional orien...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-20 | PXD058006 | Pride
Bottom-up proteomics Lc-ms/ms 
OtherSILAC-based quantitative proteomic analysis of secretome between activated and reverted hepatic stellate cells.
Data from ProteomeXchange, PXD ID: PXD000773. File: zhanghongyu_20110913_13.mzml. Published as part of . From the Abstract: {{i}} Activated hepatic stellate cell (HSC) is the main myofibroblast cell in the liver fibrosis (LF). An important characteristic of the recovery of LF is not only the apopto...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310002866 | GPMDB
Resource Reanalysis 
ProteomicsGlucosidase Alpha Neutral C Promotes Influenza Virus Replication by Inhibiting Proteosome-Dependent Degradation of Hemagglutinin
The H7N9 influenza virus poses a significant threat to human health, and the mechanism by which it infects humans remains incompletely understood. Our investigation has unveiled significant insights into the role of glucosidase alpha, neutral C (ganc) gene in human H7N9 infections. Through whole gen...
ORGANISM(S): Homo Sapiens 
2025-03-10 | PXD061732 |
ProteomicsProteomic analysis of DEN and CCl4-induced hepatocellular carcinoma mouse model
DEN and CCl4-induced HCC mouse model was constructed, and the proteome of HCC and liver tissues was analyzed.
ORGANISM(S): Mus Musculus 
2024-02-04 | PXD049148 |
ProteomicsHIRA and dPCIF1 coordinately establish totipotent chromatin and control orderly ZGA in Drosophila embryos
In order to understand the molecular mechanism underlying the action of dPCIF1 in early embryos, we carried out co-immunoprecipitation (co-IP) assays followed by mass spectroscopic analysis using dPCIF1GFP-KI early embryos (0.5–1.5 hours). In this assay, we identified a large number of dPCIF1-intera...
ORGANISM(S): Drosophila Melanogaster 
2024-01-18 | PXD048659 |
ProteomicsThe TET-Sall4-BMP regulatory axis controls craniofacial cartilage development
Craniofacial microsomia (CFM) is a congenital defect that usually results from aberrant development of embryonic pharyngeal arches. However, the molecular basis of CFM pathogenesis is largely unknown. Here, we employ the zebrafish model to investigate mechanisms of CFM pathogenesis. In early embryos...
ORGANISM(S): Danio Rerio 
2024-02-02 | PXD049147 |
ProteomicsMecicago truncatula pulvinus proteomics
the pulvinus proteomics of Mecicago truncatula A17
ORGANISM(S): Medicago Truncatula 
PXD028750 |
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