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ProteomicsTumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma
CCT6A is a key subunit of the TRiC complex and is responsible for the folding and maturation of approximately 10% of newly synthesized proteins in cells. Given that different TRiC subunits exhibit substrate specificity, we hypothesized that CCT6A might act as a specific binding subunit. To test this...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD057101 | Pride
Human  pdac cell line  lc-ms  knockdown of cct6a 
ProteomicsTumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma
M2-polarized tumor-associated macrophages (TAMs) are a key factor contributing to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). While various factors within the tumor microenvironment drive their formation, the role of PDAC-derived exosomes in this process remains unclear. We aim to...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD056403 | Pride
Exosome Cct6a Pdac 
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