Sort   by:  
 Page size 
ProteomicsQuantitative Chemical Proteomics Profiling of de novo Proteins Synthesis during Starvation-Mediated Autophagy
Autophagy is an intracellular degradation mechanism in response to nutrient starvation. Via autophagy, some non-essential cellular constituents are degraded in a lysosome-dependent manner to generate biomolecules that can be utilized for maintaining the metabolic homeostasis. Although it is known th...
ORGANISM(S): Homo sapiens (Human) 
2016-10-18 | PXD003546 | Pride
Autophagy Boncat Proteomics Aha De novo protein synthesis Itraq 
ProteomicsMass Spectrum-based Identification of direct-binding proteins of TAIII-probe
This experiment utilizes a technology platform based on the Ultimate 3000 nano ultra-high-performance liquid chromatography coupled with the Q Exactive Plus high-resolution mass spectrometer, combined with database search software, to perform qualitative (or relative quantitative) analysis of protei...
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD060766 | Pride
ProteomicsA Quantitative Chemical Proteomics Approach to Profile the Specific Cellular Targets of Andrographolide, a Promising Anticancer Agent that Suppresses Tumor Metastasis
Drug target identification is a critical step towards the understanding of the mechanism of action of a drug, which will help to improve the current therapeutic regime and to expand the drug’s therapeutic potential. However, current in vitro affinity chromatography-based and in vivo activity- based ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-28 | PXD000588 | Pride
Chemical biology  drug targets*  itraq  mass spectrometry Molecular probes*   antitumor agents  metastasis 
ProteomicsHeme-activated Promiscuous Targeting of Artemisinin in Plasmodium falciparum
Plasmodium falciparum, the most pathogenic human malaria parasite, infects millions of human beings and causes a serious public health threat. Currently, the most potent anti-malarial drugs are artemisinin and its derivatives1,2. Artemisinin is a sesquiterpene lactone with an endoperoxide bridge3. T...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2015-12-17 | PXD002611 | Pride
Mechanism of action Target Artemisinin Chemical proteomics 
UnknownElectronic symptom monitoring after lung cancer surgery: establishing a core set of patient-reported outcomes for surgical oncology care in a longitudinal cohort study.
Not available
S-EPMC11486944 | biostudies-literature
UnknownNeoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Not available
S-EPMC6145832 | biostudies-literature
ProteomicsProteomic landscape of serum exosomes to identify potential therapeutic targets.
Using a tandem mass tag (TMT)-based quantitative proteomics approach, we characterized the proteomes of individual patient-derived serum exosomes, identified exosomal protein signatures specific to TNBC patients, and filtered out differentially expressed proteins.
ORGANISM(S): Homo Sapiens 
2021-08-04 | PXD027696 |
ProteomicsTargeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
The efficacy of immunotherapy against colorectal cancer (CRC) is impaired by insufficient immune cell recruitment into the tumor microenvironment. Our study shows that targeting circDNA2v, a circular RNA commonly overexpressed in CRC, can be exploited to elicit cytotoxic T-cell recruitment. CircDNA2...
ORGANISM(S): Homo Sapiens 
2024-04-11 | PXD051359 |
Sort   by:  
 Page size