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TranscriptomicsTranscription profiling of human soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione to provide insight into the cGMP-independent effects of NO
NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated dispro...
ORGANISM(S): Homo sapiens 
2007-09-11 | E-GEOD-2649 | biostudies-arrayexpress
UnknownThe vibronic state dependent predissociation of H2S: determination of all fragmentation processes.
Not available
S-EPMC9993885 | biostudies-literature
MetabolomicsResearch on the quality markers of antioxidant activity of Kai-Xin-San based on spectrum-effect relationship
Kai-Xin-San (KXS) is one of the classic famous traditional Chinese medicine prescriptions for amnesia, which has been applied for thousands of years. Modern pharmacological research has found that KXS has significant therapeutic efficacy on nervous system diseases, which is related to its antioxidan...
2023-12-21 | MTBLS8806 | MetaboLights
TranscriptomicsMicroRNA expression and regulation in human, chimpanzee, and macaque brain
Among other factors, changes in gene expression on the human evolutionary lineage have been suggested to play an important role in the establishment of human-specific phenotypes. However, the molecular mechanisms underlying these expression changes are largely unknown. Here, we have explored the rol...
ORGANISM(S): Homo sapiens 
2011-10-17 | E-GEOD-26545 | biostudies-arrayexpress
ProteomicsTemporal proteomic profiling of SH-SY5Y differentiation with retinoic acid using a FAIMS and Real-Time Searching strategy
The SH-SY5Y cell line is often used as a surrogate for neurons in cell-based studies. This cell line is frequently differentiated with all-trans retinoic acid (ATRA) over a 7-day period which confers neuron-like properties to the cells. However, no analysis of proteome remodeling has followed the pr...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD020807 | Pride
Tmtpro Eclipse Atra Sps-ms3 Multi-notch Retinoic acid 
ProteomicsProteomic analysis of secretory granules in dopaminergic neurons of Parkinson`s disease
Parkinson disease (PD) is the second most common age-related neurodegenerative disorder, which is related to neurotransmitter secretion impartment and the dysfunction of vesicle transport. Secretory granules (SGs) are a class of intracellular vesicles different from synaptic vesicles (SVs) in neuron...
ORGANISM(S): Homo sapiens (Human) 
2021-08-26 | PXD023937 | Pride
Parkinson`s disease Vesicle transport Secretory granule 
UnknownAssociation of childhood BMI trajectory with post-adolescent and adult lung function is mediated by pre-adolescent DNA methylation.
Not available
S-EPMC9335987 | biostudies-literature
ProteomicsS-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis
TDP43 inclusion bodies are widely present in the majority of patients with familial and sporadic amyotrophic lateral sclerosis (ALS). The mechanisms regulating TDP43 solubility remain incompletely understood. Here, we report that TDP43 undergoes S-acylation primarily at the Cys244 residue by the S-a...
ORGANISM(S): Homo sapiens (Human) 
2026-05-17 | PXD061643 | Pride
UnknownSynthesis of carbinoxamine via α-C(sp3)-H 2-pyridylation of O, S or N-containing compounds enabled by non-D-A-type super organoreductants and sulfoxide- or sulfide HAT reagents.
Not available
S-EPMC9517729 | biostudies-literature
UnknownPhosphoprotein Gene Contributes to the Enhanced Apoptosis Induced by Wild-Type Rabies Virus GD-SH-01 In Vitro.
Not available
S-EPMC5591860 | biostudies-literature
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