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MetabolomicsExtracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness
The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...
2023-01-17 | MTBLS6661 | MetaboLights
UnknownA Novel Three-Point Localization Method for Bladder Volume Estimation.
Not available
S-EPMC10975550 | biostudies-literature
TranscriptomicsExpression data from Th2 cell of ECM1 KO mice vs WT mice
CD4+ helper T cells are critical for immunological response. Th2 cells, a subset of CD4+ helper T cells, are responsible for asthma and other immune diseases. We found a Th2 secreted protein, ExtraCellular Matrix protein 1 (ECM1), which is highly induced by classic IL-4 signaling pathway during help...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-19707 | biostudies-arrayexpress
UnknownA dual-functional Ta/TaO x /Ru device with both nonlinear selector and resistive switching behaviors.
Not available
S-EPMC9033434 | biostudies-literature
ProteomicsThe phosphoproteomic responses of duck (Cairna moschata) to classical/novel duck reovirus infections in the spleen tissue
Duck reovirus (DRV) is a fatal member of the genus Orthoreovirus in the family Reoviridae. The disease caused by DRV leads to huge economic losses to the duck industry. Post-translational modification is an efficient strategy to enhance the immune responses to virus infection. However, the roles of ...
ORGANISM(S): Cairina moschata 
2021-09-09 | PXD016423 | Pride
Duck reovirus  immune response  pattern-recognition receptors  phosphorylation  post-translational modification 
ProteomicsComparative proteomic analysis revealed the differential responses to novel duck reovirus infection in the bursa of Fabricius of Cairna moschata
Duck reovirus (DRV) is well-studied aquatic bird virus belonging to the Orthoreovirus genus of the Reoviridae family. The bursa of Fabricius is an immunologically organ against virus invasion. However, the responses of the bursa of Fabricius of Cairna moschata to DRV infection are largely unknown. T...
ORGANISM(S): Cairina moschata 
2022-08-12 | PXD025093 | Pride
Cairna moschata  differential accumulated protein  reovirus  proteomic analysis  the bursa of fabricius 
ProteomicsUSP20 promotes T-ALL evolution by deubiquitinating modified HIF1A
Qualitative analysis of proteome is to study the types and quantities of proteome identified by samples under different conditions, and to perform functional analysis of the identified proteins, so as to provide reference information for quantitative and modification analysis of high-throughput prot...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD053080 | Pride
Usp20 Hif1a 
TranscriptomicsThe Role of Interleukin-11 in the Development of the Autoimmune Response in Multiple Sclerosis
Our results introduce interleukin (IL)-11 as a new cytokine that may play a role in the development of the autoimmune response in patients with relapsing remitting multiple sclerosis (RR MS). IL-11 was found to be the highest up-regulated cytokine in the serum and cerebrospinal fluid (CSF) from pat...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-59085 | biostudies-arrayexpress
UnknownImmune isolation-enabled nanoencapsulation of donor T cells: a promising strategy for mitigating GVHD and treating AML in preclinical models.
Not available
S-EPMC11381671 | biostudies-literature
ProteomicsProteomics insights into the molecular mechanisms of c9, t11-CLA synthesis
Cis-9, trans-11-conjugated linoleic acid (c9, t11-CLA), a functional fatty acid, is one of the research hotspots in the fields of functional dairy products development because of its multiple beneficial effects in humans and animals. In milk, most c9, t11-CLA is de novo synthesized from trans-11-oct...
ORGANISM(S): Bos taurus (Bovine) 
2022-08-12 | PXD028620 | Pride
Cis-9 Trans-11-conjugated linoleic acid  stearoyl-coa desaturase 1  mac-t cells  proteomics  functional fatty acid 
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