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MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
ProteomicsIntegrative Network Analysis Reveals USP7 Haploinsufficiency Inhibits E-protein Activity in Pediatric T-lineage Acute Lymphoblastic Leukemia (T-ALL)
USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the subgroup that has aberrant TAL1 oncogene activation. Network analysis of >200 T-ALL tran...
ORGANISM(S): Homo sapiens (Human) 
2021-03-16 | PXD023377 | Pride
Tal1 T-all Usp7 
GenomicsGlobal Mapping of H3K4me1 and H3K4me3 in human CD4+CD25+FOXP3+ Treg cells
Regulatory T cells (Treg) contribute to the crucial immunological processes of self-tolerance and immune homeostasis. However, the mechanisms underlying Treg function and cell fate decisions to differentiate between Treg and conventional T cells (Tconv) remain to be fully elucidated, especially at t...
ORGANISM(S): Homo sapiens 
2011-01-31 | E-GEOD-26427 | biostudies-arrayexpress
ProteomicsIsotopomer analysis of quiescent primary human fibroblasts
To ensure that the pool of precursor amino acids utilized for protein synthesis is completely labeled prior to the first labeling time-point, we conducted an isotopomer analysis. After adaption to media, cells were plated at a density of 500,000 cells per 10 cm plate. 8 days after plating, the confl...
ORGANISM(S): Homo sapiens (Human) 
2016-06-14 | PXD003559 | Pride
Isotopomer analysis 15n labeling 
TranscriptomicsExpression data from Th2 cell of ECM1 KO mice vs WT mice
CD4+ helper T cells are critical for immunological response. Th2 cells, a subset of CD4+ helper T cells, are responsible for asthma and other immune diseases. We found a Th2 secreted protein, ExtraCellular Matrix protein 1 (ECM1), which is highly induced by classic IL-4 signaling pathway during help...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-19707 | biostudies-arrayexpress
UnknownMitochondrial genome evaluation and implications for phylogenetic relationships of <i>Haemadipsa hainana</i> song, Zhang and Tan 1977 (Arhynchobdellida: Haemadipsidae).
Not available
S-EPMC12862844 | biostudies-literature
ProteomicsThe impact of Bisphenol A on immunity and asthmatic inheritance revealed from a major proteomics study
Environmental estrogens, such as bisphenol A (BPA) that is normally used in the manufacture of food and beverage containers, pose increasingly worrisome hazards to human and wildlife health. The adverse effects of BPA are multifaceted; while close attention has been paid to their effect on the immun...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-12-16 | PXD014275 | Pride
Bisphenol a Asthma Immune response Proteomics 
MetabolomicsThe glycosyltransferase UGT76B1 modulates N-hydroxy-pipecolic acid homeostasis and plant immunity
The trade-off between growth and defense is a critical aspect of plant immunity. Therefore, the plant immune response needs to be tightly regulated. Salicylic acid (SA) is an important plant hormone regulating defense against biotrophic pathogens. Recently, N-hydroxy-pipecolic acid (NHP) was identif...
2022-02-28 | MTBLS2334 | MetaboLights
UnknownJin-Tian-Ge ameliorates ovariectomy-induced bone loss in rats and modulates osteoblastogenesis and osteoclastogenesis in vitro.
Not available
S-EPMC9533506 | biostudies-literature
ProteomicsExpanding the Landscape of Aging via Orbitrap Astral Mass Spectrometry and Tandem Mass Tag (TMT) Integration
Aging results in progressive decline in physiological function due to the deterioration of essential biological processes, such as transcription and RNA splicing, ultimately increasing mortality risk. Although proteomics is emerging as a crucial tool for elucidating the molecular underpinnings of ag...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-03 | PXD058160 | Pride
Tandem mass tag(tmt) Proteomics Agining Mouse Orbitrap astral mass spectrometer 
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