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UnknownUpregulation of P53 promoted G1 arrest and apoptosis in human umbilical cord vein endothelial cells from preeclampsia.
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S-EPMC5649442 | biostudies-literature
ModelsPinchuck2010 - Genome-scale metabolic network of Shewanella oneidensis (iSO783)
Pinchuck2010 - Genome-scale metabolic network of Shewanella oneidensis (iSO783) This model is described in the article: Constraint-based model of Shewanella oneidensis MR-1 metabolism: a tool for data analysis and hypothesis generation. Pinchuk GE, Hill EA, Geydebrekht OV, D...
2015-07-30 | MODEL1507180036 | BioModels
MetabolomicsExploring Lipidomic Profiles and Their Correlation with Hormone Receptor and HER2 Status in Breast Cancer
Dysregulated lipid metabolism promotes the progression of various cancers, including breast cancer. This study aimed to explore the lipidomic profiles of breast cancer patients, providing insights into the correlation between lipid compositions and tumor subtypes characterized by hormone receptor (H...
2024-08-16 | MTBLS10858 | MetaboLights
TranscriptomicsLong Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB
The long noncoding MALAT1 RNA is upregulated in cancer tissues and its elevated expression is associated with hyper-proliferation, but the underlying mechanism is poorly understood. We demonstrate that MALAT1 levels are regulated during normal cell cycle progression. Genome-wide transcriptome analys...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-44240 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis among non-alcoholic fatty liver, non-alcoholic steatohepatitis, and type 2 diabetes mellitus rats
Non-alcoholic fatty liver (NAFL) has the potential to progress to non-alcoholic steatohepatitis (NASH) or to promote type 2 diabetes mellitus (T2DM). However, NASH and T2DM do not always develop coordinately. We established rat models of NAFL, NASH, and NAFL + T2DM to recapitulate different phenotyp...
ORGANISM(S): Rattus norvegicus 
2015-01-23 | E-GEOD-65220 | biostudies-arrayexpress
ProteomicsMass spectrometry–based proteomic profiling of pleural tissue
This dataset contains mass spectrometry-based proteomic data generated from pleural tissuesamples.Proteins were extracted, digested, and labeled using TMT isobaric labeling for quantitative analysis. Samples were analyzed using LC–MS/MS to profile the global proteome.The dataset includes raw mass sp...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD073793 | Pride
Mass spectrometry  lc–ms/ms  pleural tissue 
TranscriptomicsExpression profiling of long noncoding RNAs and mRNAs in uterine leiomyoma
Global protein coding gene and miRNA expression profiling studies in uterine leiomyoma showed their aberrant expression and involvement in the pathogenesis of uterine leiomyoma. But the global expression patterns and potential clinical value of long noncoding RNA (lncRNA) in uterine leiomyoma have n...
ORGANISM(S): Homo sapiens 
2014-08-14 | E-GEOD-52618 | biostudies-arrayexpress
TranscriptomicsIdentification of Common Genetic Variants that Account for Transcript Isoform Variation between Human Populations
In addition to the differences between populations in transcriptional and translational regulation of genes, alternative pre-mRNA splicing (AS) is also likely to play an important role in regulating gene expression and generating variation in mRNA and protein isoforms. Recently, the genetic contribu...
ORGANISM(S): Homo sapiens 
2010-08-19 | E-GEOD-9703 | biostudies-arrayexpress
MetabolomicsAberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

OBJECTIVE: Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced from studies in animals. The aim of the study is to characterise relationships between the intestinal microbiome composition, uraemic toxins and rena...

2020-10-20 | MTBLS700 | MetaboLights
TranscriptomicsKidney development time course
Array Design; Mouse Compugen 22K Spotted Oligo Author; Sean Grimmond Common Reference (Yes/No, ID); Yes Mouse universal Reference (Stratagene) Concentration; 100 Data processing/normalization; Lowess Normalisation GeneSpring) Developmental Stage; embryonic Diseased/Normal; normal Dye Swap; red/green...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-2282 | biostudies-arrayexpress
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