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The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
Abstract Isorhynchophylline, a tetracyclic indole alkaloid, has anti-inflammatory and antioxidant activities against cardiovascular diseases and central nervous system disorders. Acute lung injury (ALI) is a manifestation of inflammation concentrated in the lungs and has a high incidence rate and mo...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-23 | PXD050432 | Pride
Chronic intermittent hypoxia (CIH) can negatively affect hippocampal function through various molecular mechanisms. Protein acetylation, a frequently occurring modification, plays crucial roles in synaptic plasticity and cognitive processes. However, the global protein acetylation induced by CIH in ...
ORGANISM(S): Mus Musculus 
2024-02-07 | PXD049226 |
Cognitive and behavioural scales have indicated chronic intermittent hypoxia (CIH)-induced abnormalities in learning, memory, and cognition . Although earlier studies have shown that CIH impacts adult hippocampal neurogenesis and cognitive processes, the exact mechanism through which CIH affects hip...
ORGANISM(S): Mus Musculus 
2024-02-07 | PXD049225 |
AMBRA1 ubiquitinates PR to ptomote progestin resistance in endometrial cancer
ORGANISM(S): Homo Sapiens 
2026-01-04 | PXD072640 |
AMBRA1 ubiquitinates PR to ptomote progestin resistance in endometrial cancer
ORGANISM(S): Homo Sapiens 
2026-01-08 | PXD072904 |
To determine the molecular landscape of large intestinal aging, we collected 104 pieces of fresh large intestinal tissue from 26 Macaca fascicularis and performed age-, location-, and sex-resolved multi-omics analyses, including transcriptomics, proteomics, phosphoproteomics and metabolomics.
ORGANISM(S): Macaca Fascicularis Fascicularis 
2024-01-18 | PXD039361 |
Paired tumor and distant normal tissues from a cohort of 104 colon cancer patients were collected at West China Hospital and snap-frozen in liquid nitrogen. The informed consent forms were signed by the participants or their family members.
ORGANISM(S): Homo Sapiens 
2023-01-11 | PXD039360 |
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