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ProteomicsRegion resolved multi-omics of the mouse eye
Here, we presented an atlas of region resolved proteome and lipidome of mouse eye. The multiphoton microscopy-guided laser microdissection combined with in depth label-free proteomics, enable us to identify 13,536 proteins in 11 regions of mouse eye. Further integrative analysis of label-free proteo...
ORGANISM(S): Mus Musculus 
2023-01-14 | PXD039460 |
ProteomicsTime- and dose-resolved proteome of PM2.5 exposure in rat model
this paper used Mass spectrometry, Fast-seq, and catTFRE to study the pattern of 6316 proteins as well as 387 Transcription factors associated with PM2.5 in both short-term and long-term rat injury models.
ORGANISM(S): Rattus Norvegicus 
2020-05-27 | PXD019404 |
ProteomicsAcross-cancer immune responses induced by nanovaccines or microvaccines to prevent different cancers and cancer metastasis
Cancer vaccines, reassembled from whole tumor tissue components, were applied to demonstrate the across-cancer immune responses, thanks to inducing pan-clones T cells immune responses. It is demonstrated that across-cancer immune responses among different types of cancers exist and can be induced by...
ORGANISM(S): Mus Musculus 
2022-10-24 | PXD037688 |
ProteomicsRegion and cell-type resolved multi-omic altas of the heart
This work presented the panoramic heart proteome map, and served as the rich resource for heart researches in the future.
ORGANISM(S): Homo Sapiens Rattus Norvegicus Mus Musculus 
2025-02-17 | PXD060863 |
ProteomicsProteogenomic Characterization of Skull-base Chordoma
Skull-base chordoma (SBC) is a rare, aggressive bone cancer with a high recurrent rate. Genomic studies of SBC have improved our understanding of the disease’s biology. However, the molecular biological characteristics and the effective therapy of SBC remain unknown. Here, we carried out an integrat...
ORGANISM(S): Homo Sapiens 
2024-07-01 | PXD053550 |
ProteomicsProteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms
This dataset include the proteomic data of 243 glioma tumor tissues (discovery: 187, validation: 56); 56 tumor-adjacent tissues (discvoery: 35, validation: 21); 12 normal brain tissues; corresponding phosphoproteomic data
ORGANISM(S): Homo Sapiens 
2022-12-12 | PXD038732 |
ProteomicsProteogenomics of urothelial bladder cancer progression reveals the distinguished molecular features of different pathological subtypes
We reported a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA sequencing, and proteomics and phosphoproteomics profiling, of 448 trace-tumor-samples from 190 urothelial bladder neoplasm patients, covering the whole spectrum of disease stages and grades. DNA damage was a...
ORGANISM(S): Homo Sapiens 
2023-08-02 | PXD043775 |
ProteomicsIntegrated Proteogenomic Characterization across Major Histological Types of Pituitary Neuroendocrine Tumors
Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due to its extensive tumor heterogeneity and the lack of high-quality tissues for biomarker discovery, the causative molecular mechanisms are far from being fully defined. Therefore, more studies are needed to imp...
ORGANISM(S): Homo Sapiens 
2022-10-17 | PXD031467 |
ProteomicsMyeloid PTEN promotes chemotherapy-induced NLRP3 inflammasome activation and antitumor immunity
In this study, we found that myeloid PTEN can determine chemotherapy responsiveness by promoting NLRP3-dependent antitumor immunity and suggest that it might be a potential biomarker to predict the chemotherapy responses and manipulating NLRP3/IL-1might be able to overcome the chemotherapy resista...
ORGANISM(S): Homo Sapiens 
2020-04-16 | PXD018597 |
ProteomicsProteomics of the Gastric cancer Response to anti-PD1 therapy
To validate the correlation between Th1/Th2 ratio and immunotherapeutic effectiveness, we collected a group of GC patients treated with anti-PD1 therapy, including 7 responder cases (PR) and 7 non-responder cases (SD/PD). The formalin-fixed paraffin-embedded (FFPE) tumor tissue sections derived from...
ORGANISM(S): Homo Sapiens 
2022-11-17 | PXD038188 |
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