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GenomicsAn alternative pluripotent state confers interspecies chimaeric competency [WGBS]
In this study, we show that by simple modulation of extrinsic signaling pathways, a new class of pluripotent stem cells, referred to as region selective epiblast stem cells (rsEpiSCs), could be efficiently derived from different stages of the early embryo. rsEpiSCs share features of primed pluripote...
ORGANISM(S): Mus musculus 
2015-05-06 | E-GEOD-63568 | biostudies-arrayexpress
UnknownSynthesis and cytotoxic studies of novel 5-phenylisatin derivatives and their anti-migration and anti-angiogenic evaluation.
Not available
S-EPMC7115506 | biostudies-literature
ProteomicsNrf2-mediated enhancer activation via phase separation ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease
Mitochondrial dysfunction is emerging as a crucial contributor to the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD), but the molecular mechanisms underlying the disturbed mitochondrial homeostasis in cystic cells remain elusive. In the present study, we identify impaired activ...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-12 | PXD016312 | Pride
Lc-msms Mouse Kidney Adpkd 
ProteomicsNuclear condensation of CDYL links histone crotonylation and cystogenesis in autosomal dominant polycystic kidney disease
We identify the Kcr sites on histones that are targeted by CDYL in ADPKD cells (WT9-12 cells). We chose to knock out CDYL in WT 9-12 cells (CDYL KO) through CRISPR/Cas9-mediated gene editing to increase the overall levels of histone Kcr. We quantified Kcr modifications on different histone residues ...
ORGANISM(S): Homo Sapiens 
2022-01-17 | PXD031029 |
TranscriptomicsRNA-seq of naive and primed ES cells (NHSM)
Here we propose a set of molecular criteria for evaluating the naive human pluripotent state. We show by RNA-seq that transcription of transposable elements provides a sensitive measure of the concordance between pluripotent stem cells and early human development. RNA-seq of 3 naive ES samples in NH...
ORGANISM(S): Homo sapiens 
2016-08-16 | E-GEOD-85689 | biostudies-arrayexpress
UnknownMultiomics dissection of Brassica napus L. lateral roots and endophytes interactions under phosphorus starvation.
Not available
S-EPMC11551189 | biostudies-literature
Proteomicshead and neck cancer cells label free proteomics
label-free proteomics for EIF3B knockdown and Control Fadu cells
ORGANISM(S): Homo Sapiens 
PXD021532 |
ProteomicsEffect of potato glycoside alkaloids on mitochondrial protein of Fusarium solani
Effect of Potato Glycoside Alkaloids on Mitochondria Energy Metabolism of Fusarium solani, the Root Rot Pathogen of Lycium Barbarum.
ORGANISM(S): Fusarium Solani F. Sp. Glycines 
2024-12-16 | PXD058927 |
UnknownSelection criteria for large core trials: rationale for the ANGEL-ASPECT study design.
Not available
S-EPMC8785010 | biostudies-literature
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