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UnknownThe PRR11-SKA2 Bidirectional Transcription Unit Is Negatively Regulated by p53 through NF-Y in Lung Cancer Cells.
We previously identified proline-rich protein 11 (PRR11) as a novel cancer-related gene that is implicated in the regulation of cell cycle and tumorigenesis. Our recent study demonstrated that PRR11 and its adjacent gene, kinetochore associated 2 (SKA2), constitute...
S-EPMC5372550 | biostudies-literature
UnknownGraphCpG: imputation of single-cell methylomes based on locus-aware neighboring subgraphs.

Motivation

Single-cell DNA methylation sequencing can assay DNA methylation at single-cell resolution. However, incomplete coverage compromises related downstream analyses, outlining the importance of imputation techniques. With a rising number of cell samples in recent large datasets, scala...
S-EPMC10516632 | biostudies-literature
UnknownBibliometric analysis of global research trends in delivery systems for breast cancer immunotherapy.

Background

Breast cancer (BC) immunotherapy exhibits disappointingly low response rates and faces significant challenges including systemic toxicity and poor tumor penetration, while delivery systems (DSs) offer revolutionary capacity to enhance efficacy and minimize adverse effects. Despite...
S-EPMC12508343 | biostudies-literature
UnknownEffects of Long-Term Heavy Metal Exposure on Oral Microbial Antibiotic Resistance Genes of Residents in the Mining and Smelting Area.
Growing evidence highlights the role of heavy metals in driving the co-selection of an-tibiotic resistance genes (ARGs), and the human oral cavity is an important reservoir of ARGs. This cross-sectional study investigated the effects of heavy metal exposure on human oral microbiota and ARGs, collect...
S-EPMC12736263 | biostudies-literature
UnknownStudy of the distribution of Glycyrrhiza uralensis production areas as well as the factors affecting yield and quality.
Wild licorice in China is mainly distributed in northern China, such as Gansu, Ningxia, and Inner Mongolia Provinces. The origin of wild licorice has varied among historical periods. The cultivated origin of planted licorice has the same as 59.26% of wild licorice. The distribution of cultivated lic...
S-EPMC10060575 | biostudies-literature
UnknownIdentification of Y‒linked biomarkers and exploration of immune infiltration of normal-appearing gray matter in multiple sclerosis by bioinformatic analysis.

Background

The knowledge of normal‒appearing cortical gray matter (NAGM) in multiple sclerosis (MS) remains unclear. In this study, we aimed to identify diagnostic biomarkers and explore the immune infiltration characteristics of NAGM in MS through bioinformatic analysis and validation in...
S-EPMC10956066 | biostudies-literature
UnknownIntegrative multi-omics and single-cell transcriptomics reveal ARHGEF12 driving chemoresistance in bladder cancer.
Bladder cancer (BLCA) is the predominant type of urothelial carcinoma in urinary system, and resistance to cisplatin-based chemotherapy substantially worsens clinical outcomes, presenting a major therapeutic obstacle. In this study, we integrated genome-wide association study (GWAS) data with expres...
S-EPMC12661753 | biostudies-literature
ProteomicsGilvimarinus xylanilyticus strain HB14T,LC-MSMS
Strain HB14T was cultivated on 1,3-xylan and Detected its extracellular 1,3-xylanases.
ORGANISM(S): Gilvimarinus sp. HB14 
2022-10-18 | PXD035564 | Pride
1 3-xylan Gilvimarinus xylanilyticus strain hb14t Lc-msms 
ProteomicsAlginate metabolic pathways of the strain C42 associated with Sargassum
Based on the genome sequencing and gene annotation, we analyzed the alginate lyases and other genes related to alginate metabolism of strain Vibrio sp. C42, with the highest alginate-degrading activity. Combined with proteome measurement, we proposed its alginate metabolic pathways.
ORGANISM(S): Vibrio atlanticus 
2026-06-04 | PXD037554 | Pride
Alginate Sargassum Alginate lyase Alginate metabolic pathway Vibrio 
UnknownImmunomolecular assay based on selective virion capture by spike antibody and viral nucleic acid amplification for detecting intact SARS-CoV-2 particles.

Background

Effective therapeutics and vaccines for coronavirus disease 2019 (COVID-19) are currently lacking because of the mutation and immune escape of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on the propagation characteristics of SARS-CoV-2, rapid and accurate d...
S-EPMC9444083 | biostudies-literature
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