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The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear. Here, we demonstrated that a strain affiliated with Lactobacillus plantarum (de...
2024-01-16 | MTBLS4262 | MetaboLights
Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma
ORGANISM(S): Homo 
Hyperglycemia accelerates calcification of atherosclerotic plaques in diabetic patients, and the prolonged accumulation of advanced glycation end products (AGEs) induced by hyperglycemia may be closely related to the pathogenesis of aortic calcification. However, the mechanisms underlying this assoc...
ORGANISM(S): Homo Sapiens 
We identify the protein interaction of PALM2 in HEK 293T. we find that PALM2 can promote the malignant behaviors of esophageal squamous cancer cell (ESCC). Focusing on the mechanism inside, we reveal that PALM2 promotes the migration of esophageal squamous cancer cells through activating it interact...
ORGANISM(S): Homo Sapiens 
2023-03-08 | PXD040700 |
Proteins containing a CAAX motif at the C-terminus can occur prenylation modification and regulate the localization and activity of a series of key regulatory proteins, including RAS superfamily members, heterotrimeric G proteins, nuclear lamina protein, and several protein kinases and phosphatases....
ORGANISM(S): Homo Sapiens 
2023-03-20 | PXD040969 |
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