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TranscriptomicsMouse Marginal Zone B-cell with/without Tfh RNASeq data analysis
Mouse Marginal Zone B-cell with/without Tfh
ORGANISM(S): Mus musculus 
2024-01-24 | E-MTAB-11677 | biostudies-arrayexpress
ProteomicsSSR4 deficiency in B-cell reshapes the inflammatory microenvironment
The development and differentiation of infiltrating B cells influence the structure of the immune microenvironment (TIME). We aimed to unveil the impact of regulating B cell development and antibodies secretion by glycosylation modification-associated protein SSR4 on the formation of IME structures ...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD058527 | Pride
Mouse，b cells Ssr4 deficiency 
ProteomicsABPP of Ibrutinib Resistance in B Cell Malignancies
Ibrutinib,a novel Bruton'styrosine kinase inhibitor, demonstrated high response rates in B-cell lymphomas but a growing number of ibrutinib treated patients relapse with resistance, fulminant progression and accelerated mortality. Using chemical proteomics and a high-throughput ex vivo assay in a re...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005734 | Pride
Ibrutinib Activity-based protein profiling B-cell cancers Lc-ms/ms 
ProteomicsProteomic Profiling and Functional Analysis of B Cell-Derived Exosomes upon Pneumocystis Infection
Pneumocystis is a life-threatening fungal pathogen frequently causing fatal pneumonia (PCP) in immunocompromised individuals with high mortality. Recently, B cells have been reported to play a crucial role in the pathogenesis of PCP through producing antibodies and activating CD4+ T cell response. E...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-26 | PXD030103 | Pride
Exosomes Mass spectrometry B lymphocytes Pneumocystis pneumonia 
TranscriptomicsIdentification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma
LMO2 regulates gene expression facilitating the formation of multipartite DNA-binding complexes. In B cells, LMO2 is specifically up-regulated in the Germinal Center (GC) reaction and is expressed in GC-derived non-Hodgkin’s lymphomas. LMO2 is one of the most powerful prognostic indicators in DLBCL ...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-34576 | biostudies-arrayexpress
TranscriptomicsExploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma
Knowledge of essential oncogenic mutations can inspire therapeutic strategies that are synthetically lethal, affecting cancer cells bearing an oncogenic mutation while sparing normal cells. Lenalidomide is emerging as an active agent in diffuse large B cell lymphoma (DLBCL), especially for the activ...
ORGANISM(S): Homo sapiens 
2012-08-16 | E-GEOD-33012 | biostudies-arrayexpress
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
ProteomicsMulti-omics Analysis of naive B cells of patients harboring the C104R mutation in TACI
Common variable immunodeficiency (CVID) is the most prevalent form of symptomatic primary immunodeficiency in humans. The genetic cause of CVID is still unknown in about 70% of cases. 10% of CVID patients carry heterozygous mutations in the tumor necrosis factor receptor superfamily member 13B gene ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035459 | Pride
Atac-seq Cd40l stimulation Dna accessibility Proteomics Taci Tnfrsf13b Transcription factor Cvid Naïve b cells Nf-b Rna-seq 
ProteomicsDeletion of miR-15a/16-1 in murine germinal center B-cells.
Given the tumor suppressing function of miR-15a/16-1 cluster, we studied its role in the germinal center B-cells that give rise to most lymphoid malignancies.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD021323 | Pride
B-cell Proteomics Mouse Germinal center 
GenomicsEpstein-Barr Virus Exploits Intrinsic B-Lymphocyte Transcription Programs to Achieve Immortal Cell Growth
Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) gene regulation through the cell RBPJ transcription factor (TF) is essential for conversion of resting B-lymphocytes (RBLs) into Lymphoblastoid Cell Lines (LCLs). ChIP-seq investigation of EBNA2 and RBPJ sites in LCL DNA found EBNA2 at 5151 and RBPJ at 10...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-29498 | biostudies-arrayexpress
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