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UnknownGenetic Characterization of Primordial Germ Cells in Spotted Sea Bass (<i>Lateolabrax maculatus</i>).
Not available
S-EPMC12470244 | biostudies-literature
ProteomicsThe Pharmacological Effect and Mechanism of Lanthanum Hydroxide on Vascular Calcification Caused by Chronic Renal Failure Hyperphosphatemia
Objective: To investigate the treatment and mechanism of lanthanum hydroxide on hyperphosphate-induced vascular calcification in chronic renal failure. Methods: Develop a rat model of CKD hyperphosphatemia. Rats were randomly allocated to the model, lanthanum hydroxide, lanthanum carbonate, Calcium...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-09 | PXD023081 | Pride
Hyperphosphatemia Vascular calcification Lanthanum hydroxide Mechanism Pharmacological effect Chronic renal failure 
UnknownMitigating the effects of Xuebijing injection on hematopoietic cell injury induced by total body irradiation with γ rays by decreasing reactive oxygen species levels.
Not available
S-EPMC4100167 | biostudies-literature
ProteomicsMulti-Omics Analysis Reveals RNA Polymerase II Degradation as a Novel Mechanism of PF-3758309's Anti-Tumor Activity
In this study, we conducted a comprehensive multi-omics analysis, including proteomics, transcriptomics, and ubiquitinomics, to investigate the mechanism of PF-3758309 in HCT116 cells. Our results revealed that PF-3758309 promotes the degradation of RNA polymerase II subunit proteins (POLR2A/B/E) vi...
ORGANISM(S): Homo Sapiens 
2025-06-05 | PXD064705 |
ProteomicsA Micro-Quantitative and FFPE-compatible Workflow for Im- 2 munohistochemistry-Guided Spatial Proteomic Analysis of 3 Cellular Subpopulations within the Tumor Microenvironment
Understanding the spatial proteomic landscape of human tumors is essential for dissecting cellular heterogeneity and microenvironmental interactions in cancer biology. Traditional bulk proteomic approaches, however, obscure spatial information and average out signals from distinct cell populations. ...
ORGANISM(S): Homo Sapiens 
2026-05-14 | PXD078338 |
ProteomicsProteomic and phosphoproteomic maps of lung squamous cell carcinoma from Chinese patients
Lung cancer in Chinese patients has distinct genomic features and lung squamous cell carcinoma (LUSC) has limited biomarkers for targeted therapy even though a lot of progress has been made in genomics research. Systematical research on LUSC at protein level will be beneficial to improve precision m...
ORGANISM(S): Homo Sapiens 
2020-05-16 | PXD019234 |
ProteomicsAKR1B10 inhibition enhances c-Myc stability by disrupting PP2A assembly
Immunoprecipitation-MS analysis to identify AKR1B10 interacting proteins.
ORGANISM(S): Homo Sapiens 
2025-06-26 | PXD058680 |
ProteomicsSIRT2 regulates extracellular vesicle-mediated liver-bone communication
The interplay between liver and bone metabolism remains largely uncharacterized. Here, we uncover a mechanism of liver-bone crosstalk regulated by hepatocyte SIRT2. We demonstrate that hepatocyte SIRT2 expression is increased in aged mice and elderly humans. Liver-specific SIRT2 deficiency inhibits ...
ORGANISM(S): Mus Musculus 
2023-03-27 | PXD041145 |
ProteomicsGlobal identification ofphospho-dependent SCF ubiquitin ligase substrate reveal a role of ERK-FBXO22-BAG3 axis in tumorigenesis
293T cells were cultured in SILAC medium. Heavy group was labeled with K6&R10. Light group was labeled with K0&R0. In light group, cells were treated with MLN4924. In heavy group, cells were treated with DMSO. Then cells were lysed, mixed and tryptic digested. Peptide mixture was subjected to phosph...
ORGANISM(S): Homo Sapiens 
2021-06-29 | PXD027020 |
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